Probes for CpG islands on the distal long arm of the human X chromosome are clustered in Xq24 and Xq28

Elena Maestrini, Stefano Rivella, Carla Tribioli, David Purtilo, Mariano Rocchi, Nicoletta Archidiacono, Daniela Toniolo

Research output: Contribution to journalArticle

Abstract

We have isolated and characterized 55 EagI-containing genomic DNA clones from the distal long arm of the human X chromosome. The presence of additional sites for rarecutter restriction enzymes and the demethylation of the corresponding genomic DNA demonstrate that at least 30 clones correspond to CpG islands of the Xq24-Xqter region. All clones were regionally mapped with a hybrid panel. The majority are in Xq28 and Xq24 (18 and 14 clones, respectively), 15 are in the Xq26-Xq27 interval, and none is in Xq25. This analysis demonstrates a nonuniform distribution of CpG islands that may reflect the distribution of coding regions in this part of the genome.

Original languageEnglish
Pages (from-to)664-670
Number of pages7
JournalGenomics
Volume8
Issue number4
DOIs
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Genetics

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