Probing axons using multi-compartmental diffusion in multiple sclerosis

Francesca Bagnato, Giulia Franco, Hua Li, Enrico Kaden, Fei Ye, Run Fan, Amalie Chen, Daniel C. Alexander, Seth A. Smith, Richard Dortch, Junzhong Xu

Research output: Contribution to journalArticle

Abstract

Objects: The diffusion-based spherical mean technique (SMT) provides a novel model to relate multi-b-value diffusion magnetic resonance imaging (MRI) data to features of tissue microstructure. We propose the first clinical application of SMT to image the brain of patients with multiple sclerosis (MS) and investigate clinical feasibility and translation. Methods: Eighteen MS patients and nine age- and sex-matched healthy controls (HCs) underwent a 3.0 Tesla scan inclusive of clinical sequences and SMT images (isotropic resolution of 2 mm). Axial diffusivity (AD), apparent axonal volume fraction (Vax), and effective neural diffusivity (Dax) parametric maps were fitted. Differences in AD, Vax, and Dax between anatomically matched regions reflecting different tissues types were estimated using generalized linear mixed models for binary outcomes. Results: Differences were seen in all SMT-derived parameters between chronic black holes (cBHs) and T2-lesions (P ≤ 0.0016), in Vax and AD between T2-lesions and normal appearing white matter (NAWM) (P < 0.0001), but not between the NAWM and normal WM in HCs. Inverse correlations were seen between Vax and AD in cBHs (r = −0.750, P = 0.02); in T2-lesions Dax values were associated with Vax (r = 0.824, P < 0.0001) and AD (r = 0.570, P = 0.014). Interpretations: SMT-derived metrics are sensitive to pathological changes and hold potential for clinical application in MS patients.

Original languageEnglish
Pages (from-to)1595-1605
JournalAnnals of Clinical and Translational Neurology
Volume6
Issue number9
DOIs
Publication statusPublished - Jan 1 2019

    Fingerprint

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Bagnato, F., Franco, G., Li, H., Kaden, E., Ye, F., Fan, R., Chen, A., Alexander, D. C., Smith, S. A., Dortch, R., & Xu, J. (2019). Probing axons using multi-compartmental diffusion in multiple sclerosis. Annals of Clinical and Translational Neurology, 6(9), 1595-1605. https://doi.org/10.1002/acn3.50836