Probing cytoskeleton organisation of neuroblastoma cells with single-cell force spectroscopy

Andrea Mescola, Serena Vella, Marco Scotto, Paola Gavazzo, Claudio Canale, Alberto Diaspro, Aldo Pagano, Massimo Vassalli

Research output: Contribution to journalArticlepeer-review

Abstract

Single-cell force spectroscopy is an emerging technique in the field of biomedicine because it has proved to be a unique tool to obtain mechanical and functional information on living cells, with force resolution up to single molecular bonds. This technique was applied to the study of the cytoskeleton organisation of neuroblastoma cells, a life-threatening cancer typically developing during childhood, and the results were interpreted on the basis of reference experiments on human embryonic kidney cell line. An intimate connection emerges among cellular state, cytoskeleton organisation and experimental outcome that can be potentially exploited towards a new method for cancer stadiation of neuroblastoma cells.

Original languageEnglish
Pages (from-to)270-277
Number of pages8
JournalJournal of molecular recognition : JMR
Volume25
Issue number5
DOIs
Publication statusPublished - May 2012

Keywords

  • AFM
  • Cytoskeleton
  • Neuroblastoma
  • SCFS

ASJC Scopus subject areas

  • Molecular Biology
  • Structural Biology

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