Probing the reaching-grasping network in humans through multivoxel pattern decoding

Maria Grazia Di Bono, Chiara Begliomini, Umberto Castiello, Marco Zorzi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Introduction: The quest for a putative human homolog of the reaching-grasping network identified in monkeys has been the focus of many neuropsychological and neuroimaging studies in recent years. These studies have shown that the network underlying reaching-only and reach-to-grasp movements includes the superior parieto-occipital cortex (SPOC), the anterior part of the human intraparietal sulcus (hAIP), the ventral and the dorsal portion of the premotor cortex, and the primary motor cortex (M1). Recent evidence for a wider frontoparietal network coding for different aspects of reaching-only and reach-to-grasp actions calls for a more fine-grained assessment of the reaching-grasping network in humans by exploiting pattern decoding methods (multivoxel pattern analysis-MVPA). Methods: Here, we used MPVA on functional magnetic resonance imaging (fMRI) data to assess whether regions of the frontoparietal network discriminate between reaching-only and reach-to-grasp actions, natural and constrained grasping, different grasp types, and object sizes. Participants were required to perform either reaching-only movements or two reach-to-grasp types (precision or whole hand grasp) upon spherical objects of different sizes. Results: Multivoxel pattern analysis highlighted that, independently from the object size, all the selected regions of both hemispheres contribute in coding for grasp type, with the exception of SPOC and the right hAIP. Consistent with recent neurophysiological findings on monkeys, there was no evidence for a clear-cut distinction between a dorsomedial and a dorsolateral pathway that would be specialized for reaching-only and reach-to-grasp actions, respectively. Nevertheless, the comparison of decoding accuracy across brain areas highlighted their different contributions to reaching-only and grasping actions. Conclusions: Altogether, our findings enrich the current knowledge regarding the functional role of key brain areas involved in the cortical control of reaching-only and reach-to-grasp actions in humans, by revealing novel fine-grained distinctions among action types within a wide frontoparietal network.

Original languageEnglish
Article numbere00412
JournalBrain and Behavior
Volume5
Issue number11
DOIs
Publication statusPublished - Nov 1 2015

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Hand Strength
Occipital Lobe
Parietal Lobe
Motor Cortex
Haplorhini
Brain
Neuroimaging
Hand
Magnetic Resonance Imaging

Keywords

  • Functional magnetic resonance imaging
  • Multivoxel pattern decoding
  • Reaching-only action
  • Visuomotor reach-to-grasp action

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Probing the reaching-grasping network in humans through multivoxel pattern decoding. / Di Bono, Maria Grazia; Begliomini, Chiara; Castiello, Umberto; Zorzi, Marco.

In: Brain and Behavior, Vol. 5, No. 11, e00412, 01.11.2015.

Research output: Contribution to journalArticle

Di Bono, Maria Grazia ; Begliomini, Chiara ; Castiello, Umberto ; Zorzi, Marco. / Probing the reaching-grasping network in humans through multivoxel pattern decoding. In: Brain and Behavior. 2015 ; Vol. 5, No. 11.
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