Probiotics and Helicobacter pylori eradication

F. Canducci, F. Cremonini, A. Armuzzi, S. Di Caro, M. Gabrielli, L. Santarelli, E. Nista, A. Lupascu, D. De Martini, A. Gasbarrini

Research output: Contribution to journalArticlepeer-review


The need for new strategies for Helicobacter pylori eradication, alternative or complementary to antibiotic therapy, has recently claimed the attention of many investigators. Pre-clinical studies have shown the inhibition of Helicabacter pylori growth by Lactobacilli and the anti-Helicobacter pylori action of Lactobacillus salivarius, Lactobacillus acidophilus and Lactobacillus casei subspecies rhamnosus strains, possibly due to the production of lactic acid or to the secretion of an autolysin. Clinical studies have demonstrated a persistent reduction in delta over baseline values at the 13C urea breath test independently of omeprazole administration with Lactobacillus acidophilus La1, the eradication in 6 out of 14 patients with Lactobacillus acidophilus alone, positive results in patients in which a standard Helicobacter pylori triple therapy was randomly supplemented with Lactobacillus acidophilus.

Original languageEnglish
JournalDigestive and Liver Disease
Issue numberSUPPL. 2
Publication statusPublished - Sep 2002


  • Eradication
  • Helicobacter pylori

ASJC Scopus subject areas

  • Gastroenterology


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