Probiotics and vaccination in children

Michele Miraglia del Giudice, Salvatore Leonardi, Francesca Galdo, Annalisa Allegorico, Martina Filippelli, Teresa Arrigo, Carmelo Salpietro, Mario La Rosa, Chiara Valsecchi, Sara Carlotta Tagliacarne, Anna Maria Castellazzi, Gian Luigi Marseglia

Research output: Contribution to journalArticle

Abstract

Immunisation is one of the most beneficial and cost-effective disease prevention measures. However several immunisations are associated with suboptimal seroconversion rates and so the protective effect is not optimal. In the last two decades the concept about the use of probiotic bacteria as novel mucosal adjuvants has engendered a lot of interest due to our increased immunological understanding and the availability of various techniques to enhance existing vaccine specific-immune responses. Mostly in developing countries, many people still die every year from vaccine-preventable diseases such as pneumonia and diarrhea. To date, emphasis has been placed on identifying novel vaccine antigens and adjuvants that induce stronger protective immune responses, as well as developing mucosally-administered vaccines. We would have enormous benefits in allowing safe administration of vaccines in remote areas and we may overcome the necessity for multiple doses. The precise mechanism of action of probiotics is not fully understood, but several animal and human studies have proven immunomodulatory effects involving both the humoral and cellular components of the host's immune system. This review discusses whether dietary supplementation with oral probiotics enhances the immune response of infants after routine vaccinations and also evaluates clinical effects of probiotics in adults. Further well designed, randomized, placebo-controlled studies are needed to understand fully the immunomodulatory properties of probiotics, whether the effects exerted are strain and age-dependent, and their clinical relevance in enhancing protection following vaccination.

Original languageEnglish
Article number1000226
JournalJournal of Vaccines and Vaccination
Volume5
Issue number3
DOIs
Publication statusPublished - 2014

Fingerprint

Probiotics
Vaccination
Vaccines
Immunization
Cost of Illness
Dietary Supplements
Developing Countries
Diarrhea
Immune System
Pneumonia
Placebos
Bacteria
Antigens

Keywords

  • Bacteria
  • Immunization
  • Infants
  • Mucosallyadministered vaccines
  • Response
  • Seroconversion rates
  • Vaccine

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Immunology and Allergy
  • Drug Discovery

Cite this

del Giudice, M. M., Leonardi, S., Galdo, F., Allegorico, A., Filippelli, M., Arrigo, T., ... Marseglia, G. L. (2014). Probiotics and vaccination in children. Journal of Vaccines and Vaccination, 5(3), [1000226]. https://doi.org/10.4172/2157-7560.1000226

Probiotics and vaccination in children. / del Giudice, Michele Miraglia; Leonardi, Salvatore; Galdo, Francesca; Allegorico, Annalisa; Filippelli, Martina; Arrigo, Teresa; Salpietro, Carmelo; La Rosa, Mario; Valsecchi, Chiara; Tagliacarne, Sara Carlotta; Castellazzi, Anna Maria; Marseglia, Gian Luigi.

In: Journal of Vaccines and Vaccination, Vol. 5, No. 3, 1000226, 2014.

Research output: Contribution to journalArticle

del Giudice, MM, Leonardi, S, Galdo, F, Allegorico, A, Filippelli, M, Arrigo, T, Salpietro, C, La Rosa, M, Valsecchi, C, Tagliacarne, SC, Castellazzi, AM & Marseglia, GL 2014, 'Probiotics and vaccination in children', Journal of Vaccines and Vaccination, vol. 5, no. 3, 1000226. https://doi.org/10.4172/2157-7560.1000226
del Giudice MM, Leonardi S, Galdo F, Allegorico A, Filippelli M, Arrigo T et al. Probiotics and vaccination in children. Journal of Vaccines and Vaccination. 2014;5(3). 1000226. https://doi.org/10.4172/2157-7560.1000226
del Giudice, Michele Miraglia ; Leonardi, Salvatore ; Galdo, Francesca ; Allegorico, Annalisa ; Filippelli, Martina ; Arrigo, Teresa ; Salpietro, Carmelo ; La Rosa, Mario ; Valsecchi, Chiara ; Tagliacarne, Sara Carlotta ; Castellazzi, Anna Maria ; Marseglia, Gian Luigi. / Probiotics and vaccination in children. In: Journal of Vaccines and Vaccination. 2014 ; Vol. 5, No. 3.
@article{763d60ed1e4b4476aa7594323b2b3bd9,
title = "Probiotics and vaccination in children",
abstract = "Immunisation is one of the most beneficial and cost-effective disease prevention measures. However several immunisations are associated with suboptimal seroconversion rates and so the protective effect is not optimal. In the last two decades the concept about the use of probiotic bacteria as novel mucosal adjuvants has engendered a lot of interest due to our increased immunological understanding and the availability of various techniques to enhance existing vaccine specific-immune responses. Mostly in developing countries, many people still die every year from vaccine-preventable diseases such as pneumonia and diarrhea. To date, emphasis has been placed on identifying novel vaccine antigens and adjuvants that induce stronger protective immune responses, as well as developing mucosally-administered vaccines. We would have enormous benefits in allowing safe administration of vaccines in remote areas and we may overcome the necessity for multiple doses. The precise mechanism of action of probiotics is not fully understood, but several animal and human studies have proven immunomodulatory effects involving both the humoral and cellular components of the host's immune system. This review discusses whether dietary supplementation with oral probiotics enhances the immune response of infants after routine vaccinations and also evaluates clinical effects of probiotics in adults. Further well designed, randomized, placebo-controlled studies are needed to understand fully the immunomodulatory properties of probiotics, whether the effects exerted are strain and age-dependent, and their clinical relevance in enhancing protection following vaccination.",
keywords = "Bacteria, Immunization, Infants, Mucosallyadministered vaccines, Response, Seroconversion rates, Vaccine",
author = "{del Giudice}, {Michele Miraglia} and Salvatore Leonardi and Francesca Galdo and Annalisa Allegorico and Martina Filippelli and Teresa Arrigo and Carmelo Salpietro and {La Rosa}, Mario and Chiara Valsecchi and Tagliacarne, {Sara Carlotta} and Castellazzi, {Anna Maria} and Marseglia, {Gian Luigi}",
year = "2014",
doi = "10.4172/2157-7560.1000226",
language = "English",
volume = "5",
journal = "Journal of Vaccines and Vaccination",
issn = "2157-7560",
publisher = "OMICS Publishing Group",
number = "3",

}

TY - JOUR

T1 - Probiotics and vaccination in children

AU - del Giudice, Michele Miraglia

AU - Leonardi, Salvatore

AU - Galdo, Francesca

AU - Allegorico, Annalisa

AU - Filippelli, Martina

AU - Arrigo, Teresa

AU - Salpietro, Carmelo

AU - La Rosa, Mario

AU - Valsecchi, Chiara

AU - Tagliacarne, Sara Carlotta

AU - Castellazzi, Anna Maria

AU - Marseglia, Gian Luigi

PY - 2014

Y1 - 2014

N2 - Immunisation is one of the most beneficial and cost-effective disease prevention measures. However several immunisations are associated with suboptimal seroconversion rates and so the protective effect is not optimal. In the last two decades the concept about the use of probiotic bacteria as novel mucosal adjuvants has engendered a lot of interest due to our increased immunological understanding and the availability of various techniques to enhance existing vaccine specific-immune responses. Mostly in developing countries, many people still die every year from vaccine-preventable diseases such as pneumonia and diarrhea. To date, emphasis has been placed on identifying novel vaccine antigens and adjuvants that induce stronger protective immune responses, as well as developing mucosally-administered vaccines. We would have enormous benefits in allowing safe administration of vaccines in remote areas and we may overcome the necessity for multiple doses. The precise mechanism of action of probiotics is not fully understood, but several animal and human studies have proven immunomodulatory effects involving both the humoral and cellular components of the host's immune system. This review discusses whether dietary supplementation with oral probiotics enhances the immune response of infants after routine vaccinations and also evaluates clinical effects of probiotics in adults. Further well designed, randomized, placebo-controlled studies are needed to understand fully the immunomodulatory properties of probiotics, whether the effects exerted are strain and age-dependent, and their clinical relevance in enhancing protection following vaccination.

AB - Immunisation is one of the most beneficial and cost-effective disease prevention measures. However several immunisations are associated with suboptimal seroconversion rates and so the protective effect is not optimal. In the last two decades the concept about the use of probiotic bacteria as novel mucosal adjuvants has engendered a lot of interest due to our increased immunological understanding and the availability of various techniques to enhance existing vaccine specific-immune responses. Mostly in developing countries, many people still die every year from vaccine-preventable diseases such as pneumonia and diarrhea. To date, emphasis has been placed on identifying novel vaccine antigens and adjuvants that induce stronger protective immune responses, as well as developing mucosally-administered vaccines. We would have enormous benefits in allowing safe administration of vaccines in remote areas and we may overcome the necessity for multiple doses. The precise mechanism of action of probiotics is not fully understood, but several animal and human studies have proven immunomodulatory effects involving both the humoral and cellular components of the host's immune system. This review discusses whether dietary supplementation with oral probiotics enhances the immune response of infants after routine vaccinations and also evaluates clinical effects of probiotics in adults. Further well designed, randomized, placebo-controlled studies are needed to understand fully the immunomodulatory properties of probiotics, whether the effects exerted are strain and age-dependent, and their clinical relevance in enhancing protection following vaccination.

KW - Bacteria

KW - Immunization

KW - Infants

KW - Mucosallyadministered vaccines

KW - Response

KW - Seroconversion rates

KW - Vaccine

UR - http://www.scopus.com/inward/record.url?scp=84902602894&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902602894&partnerID=8YFLogxK

U2 - 10.4172/2157-7560.1000226

DO - 10.4172/2157-7560.1000226

M3 - Article

AN - SCOPUS:84902602894

VL - 5

JO - Journal of Vaccines and Vaccination

JF - Journal of Vaccines and Vaccination

SN - 2157-7560

IS - 3

M1 - 1000226

ER -