Probiotics reduce gut microbial translocation and improve adult atopic dermatitis

Enrico Iemoli, Daria Trabattoni, Serena Parisotto, Linda Borgonovo, Marco Toscano, Giuliano Rizzardini, Mario Clerici, Elena Ricci, Alessandra Fusi, Elena De Vecchi, Stefania Piconi, Lorenzo Drago

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Abstract

BACKGROUND:: It has been suggested that probiotics modulate atopic dermatitis (AD) progression, but no data are actually available on their mechanisms of action and on their ability to act as immunomodulators in this pathology. OBJECTIVE:: The aim of this randomized double-blinded active treatment versus placebo study was to evaluate clinical efficacy of an intake of a combination of 2 probiotics (Lactobacillus salivarius LS01 and Bifidobacterium breve BR03) for the treatment of adult AD patients. METHODS:: Forty-eight patients were enrolled in the study (randomization ratio 2:1) and treated with a combination (LS01 and BR03) or placebo (maltodextrin) for 12 weeks. Clinical efficacy was assessed from baseline by changes in the SCORAD index and DLQ index improvement. Analysis on the gut permeability barrier, immunologic parameters, and changes in fecal microbiota and recovery of probiotics were performed at baseline, at the end of therapy, and 2 months later. RESULTS:: Patients receiving probiotics showed a significant improvement in clinical parameters (SCORAD, P

Original languageEnglish
JournalJournal of Clinical Gastroenterology
Volume46
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Oct 2012

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Keywords

  • atopic dermatitis
  • microbiota
  • probiotics
  • regulatory T cells
  • T-helper cells

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Iemoli, E., Trabattoni, D., Parisotto, S., Borgonovo, L., Toscano, M., Rizzardini, G., Clerici, M., Ricci, E., Fusi, A., De Vecchi, E., Piconi, S., & Drago, L. (2012). Probiotics reduce gut microbial translocation and improve adult atopic dermatitis. Journal of Clinical Gastroenterology, 46(SUPPL. 1). https://doi.org/10.1097/MCG.0b013e31826a8468