Probiotics reduce gut microbial translocation and improve adult atopic dermatitis

Enrico Iemoli; Daria Trabattoni; Serena Parisotto; Linda Borgonovo; Marco Toscano; Giuliano Rizzardini; Mario Clerici; Elena Ricci; Alessandra Fusi; Elena De Vecchi; Stefania Piconi; Lorenzo Drago

doi:10.1097/MCG.0b013e31826a8468

Probiotics reduce gut microbial translocation and improve adult atopic dermatitis

Enrico Iemoli, Daria Trabattoni, Serena Parisotto, Linda Borgonovo, Marco Toscano, Giuliano Rizzardini, Mario Clerici, Elena Ricci, Alessandra Fusi, Elena De Vecchi, Stefania Piconi, Lorenzo Drago

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND:: It has been suggested that probiotics modulate atopic dermatitis (AD) progression, but no data are actually available on their mechanisms of action and on their ability to act as immunomodulators in this pathology. OBJECTIVE:: The aim of this randomized double-blinded active treatment versus placebo study was to evaluate clinical efficacy of an intake of a combination of 2 probiotics (Lactobacillus salivarius LS01 and Bifidobacterium breve BR03) for the treatment of adult AD patients. METHODS:: Forty-eight patients were enrolled in the study (randomization ratio 2:1) and treated with a combination (LS01 and BR03) or placebo (maltodextrin) for 12 weeks. Clinical efficacy was assessed from baseline by changes in the SCORAD index and DLQ index improvement. Analysis on the gut permeability barrier, immunologic parameters, and changes in fecal microbiota and recovery of probiotics were performed at baseline, at the end of therapy, and 2 months later. RESULTS:: Patients receiving probiotics showed a significant improvement in clinical parameters (SCORAD, P

Original language	English
Journal	Journal of Clinical Gastroenterology
Volume	46
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1097/MCG.0b013e31826a8468
Publication status	Published - Oct 2012

Keywords

atopic dermatitis
microbiota
probiotics
regulatory T cells
T-helper cells

ASJC Scopus subject areas

Gastroenterology

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10.1097/MCG.0b013e31826a8468

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Probiotics reduce gut microbial translocation and improve adult atopic dermatitis. / Iemoli, Enrico; Trabattoni, Daria; Parisotto, Serena; Borgonovo, Linda; Toscano, Marco; Rizzardini, Giuliano; Clerici, Mario; Ricci, Elena; Fusi, Alessandra; De Vecchi, Elena; Piconi, Stefania; Drago, Lorenzo.

In: Journal of Clinical Gastroenterology, Vol. 46, No. SUPPL. 1, 10.2012.

Research output: Contribution to journal › Article › peer-review

Iemoli, Enrico ; Trabattoni, Daria ; Parisotto, Serena ; Borgonovo, Linda ; Toscano, Marco ; Rizzardini, Giuliano ; Clerici, Mario ; Ricci, Elena ; Fusi, Alessandra ; De Vecchi, Elena ; Piconi, Stefania ; Drago, Lorenzo. / Probiotics reduce gut microbial translocation and improve adult atopic dermatitis. In: Journal of Clinical Gastroenterology. 2012 ; Vol. 46, No. SUPPL. 1.

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AU - Rizzardini, Giuliano

AU - Clerici, Mario

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AU - De Vecchi, Elena

AU - Piconi, Stefania

AU - Drago, Lorenzo

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Probiotics reduce gut microbial translocation and improve adult atopic dermatitis

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Keywords

ASJC Scopus subject areas

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