Abstract
Anticoagulant drugs affect directly or indirectly several coagulation parameters. This article is aimed at reviewing the problems encountered while testing patients on treatment and presents potential solutions. In general, it is recommended to postpone the performance of laboratory investigation upon discontinuation of the drug, preferably 2 days or more depending on the drug's half-life. If this strategy is unfeasible and patients remain on treatment, results of testing will likely be affected and result interpretation then requires great caution and knowledge of the peculiar and differential mechanism of action of the relevant anticoagulant drug being used.
| Original language | English |
|---|---|
| Pages (from-to) | 586-592 |
| Number of pages | 7 |
| Journal | Seminars in Thrombosis and Hemostasis |
| Volume | 38 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2012 |
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Keywords
- anticoagulant drugs
- direct inhibitors
- hemostasis assays
- heparins
- laboratory tests
- vitamin K antagonists
ASJC Scopus subject areas
- Hematology
- Cardiology and Cardiovascular Medicine
Cite this
Problems and solutions for testing hemostasis assays while patients are on anticoagulants. / Tripodi, Armando.
In: Seminars in Thrombosis and Hemostasis, Vol. 38, No. 6, 2012, p. 586-592.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Problems and solutions for testing hemostasis assays while patients are on anticoagulants
AU - Tripodi, Armando
PY - 2012
Y1 - 2012
N2 - Anticoagulant drugs affect directly or indirectly several coagulation parameters. This article is aimed at reviewing the problems encountered while testing patients on treatment and presents potential solutions. In general, it is recommended to postpone the performance of laboratory investigation upon discontinuation of the drug, preferably 2 days or more depending on the drug's half-life. If this strategy is unfeasible and patients remain on treatment, results of testing will likely be affected and result interpretation then requires great caution and knowledge of the peculiar and differential mechanism of action of the relevant anticoagulant drug being used.
AB - Anticoagulant drugs affect directly or indirectly several coagulation parameters. This article is aimed at reviewing the problems encountered while testing patients on treatment and presents potential solutions. In general, it is recommended to postpone the performance of laboratory investigation upon discontinuation of the drug, preferably 2 days or more depending on the drug's half-life. If this strategy is unfeasible and patients remain on treatment, results of testing will likely be affected and result interpretation then requires great caution and knowledge of the peculiar and differential mechanism of action of the relevant anticoagulant drug being used.
KW - anticoagulant drugs
KW - direct inhibitors
KW - hemostasis assays
KW - heparins
KW - laboratory tests
KW - vitamin K antagonists
UR - http://www.scopus.com/inward/record.url?scp=84866089734&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84866089734&partnerID=8YFLogxK
U2 - 10.1055/s-0032-1319769
DO - 10.1055/s-0032-1319769
M3 - Article
C2 - 22718257
AN - SCOPUS:84866089734
VL - 38
SP - 586
EP - 592
JO - Seminars in Thrombosis and Hemostasis
JF - Seminars in Thrombosis and Hemostasis
SN - 0094-6176
IS - 6
ER -