TY - JOUR
T1 - Problems arising during chronic treatment with L-dopa for Parkinson's disease
T2 - changes in response to treatment.
AU - Caraceni, T. A.
AU - Girotti, F.
AU - Giovannini, P.
AU - Parati, E.
PY - 1986
Y1 - 1986
N2 - Some aspects of the problems of long-term L-dopa treatment syndrome are reviewed, with special attention to the changes in response to treatment with dopaminergic agents, specifically end-of-dose deterioration, the on-off phenomenon and hyperkinesia. The various hypotheses for interpreting these are presented, with particular stress on changes in the function of DA-ergic receptors. It is concluded that the on-off phenomenon is probably related to changes in plasma L-dopa levels and to decreased stores of intraneural dopamine.
AB - Some aspects of the problems of long-term L-dopa treatment syndrome are reviewed, with special attention to the changes in response to treatment with dopaminergic agents, specifically end-of-dose deterioration, the on-off phenomenon and hyperkinesia. The various hypotheses for interpreting these are presented, with particular stress on changes in the function of DA-ergic receptors. It is concluded that the on-off phenomenon is probably related to changes in plasma L-dopa levels and to decreased stores of intraneural dopamine.
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M3 - Article
C2 - 3537210
AN - SCOPUS:0022962797
VL - 22
SP - 189
EP - 199
JO - Journal of Neural Transmission, Supplement
JF - Journal of Neural Transmission, Supplement
SN - 0303-6995
ER -