Abstract
Some aspects of the problems of long-term L-dopa treatment syndrome are reviewed, with special attention to the changes in response to treatment with dopaminergic agents, specifically end-of-dose deterioration, the on-off phenomenon and hyperkinesia. The various hypotheses for interpreting these are presented, with particular stress on changes in the function of DA-ergic receptors. It is concluded that the on-off phenomenon is probably related to changes in plasma L-dopa levels and to decreased stores of intraneural dopamine.
| Original language | English |
|---|---|
| Pages (from-to) | 189-199 |
| Number of pages | 11 |
| Journal | Journal of Neural Transmission, Supplement |
| Volume | 22 |
| Publication status | Published - 1986 |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Caraceni, T. A., Girotti, F., Giovannini, P., & Parati, E. (1986). Problems arising during chronic treatment with L-dopa for Parkinson's disease: changes in response to treatment. Journal of Neural Transmission, Supplement, 22, 189-199.