Problems in daily motor performances in Parkinson's disease: the continuous dopaminergic stimulation.

F. Stocchi, S. Ruggieri, G. Brughitta, A. Agnoli

Research output: Contribution to journalArticlepeer-review

Abstract

Fluctuations in motor performances are the major problem in the longterm management of Parkinson's disease. In this study the clinical effects of L-dopa intravenous infusion were evaluated in 18 parkinsonian patients with fluctuations. 14 out of these were given Lisuride intravenous infusion in a following study. Lisuride is a potent dopamine agonist and it is highly soluble in water. The results obtained with L-dopa were very good and we found a close correlation between oral and intravenous dosage. The dosage of L-dopa infusion ranged between 360-1,250 mg for 12 hours. Lisuride proved to be able to give prolonged mobile state in 8 patients out of 14. The other 6 patients showed a different response to the drug. The dosage used ranged between 0.6 and 2.4 mg per day. No severe side-effects were observed during both studies except for nausea and vomiting occurring during Lisuride infusion.

Original languageEnglish
Pages (from-to)209-218
Number of pages10
JournalJournal of Neural Transmission, Supplement
Volume22
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Problems in daily motor performances in Parkinson's disease: the continuous dopaminergic stimulation.'. Together they form a unique fingerprint.

Cite this