Procalcitonin as a useful marker of infection in hemato-oncological patients with fever

Maria T. Sandri, Rita Passerini, Maria E. Leon, Fedro A. Peccatori, Laura Zorzino, Michela Salvatici, Daniela Riggio, Cristina Cassatella, Saverio Cinieri, Giovanni Martinelli

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The diagnostic utility of procalcitonin (PCT) and C-reactive protein (CRP) to discriminate between infective fever and fever due to inflammation was assessed in hemato-oncological patients treated with aggressive chemotherapy. Patients and Methods: Values of PCT and PCR measured on days -1, 0, 1, 3 and 5 of onset of fever were analyzed using longitudinal regression analysis. Of 236 febrile episodes in 166 patients, 39 were due to bacteremia, 62 to other infections and 135 were classified as fever of unknown origin. Results: PCT concentration increased early only in bacteremia and other infections (p

Original languageEnglish
Pages (from-to)3061-3065
Number of pages5
JournalAnticancer Research
Volume28
Issue number5 B
Publication statusPublished - Sep 2008

Keywords

  • C-reactive protein
  • Infection
  • Leukopenia
  • Procalcitonin

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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