Procalcitonin-guided antibiotic therapy: an expert consensus

Michele Bartoletti, Massimo Antonelli, Francesco Arturo Bruno Blasi, Ivo Casagranda, Arturo Chieregato, Roberto Fumagalli, Massimo Girardis, Filippo Pieralli, Mario Plebani, Gian Maria Rossolini, Massimo Sartelli, Bruno Viaggi, Pierluigi Viale, Claudio Viscoli, Federico Pea

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Procalcitonin (PCT) is a useful biomarker of bacterial infection and its use is associated to reduced duration of antibiotic therapy in the setting of intensive care medicine. To address the need of practical guidance for the use of PCT in various clinical settings, a group of experts was invited to participate at a consensus process with the aims of defining the rationale for appropriate use of PCT and for improving the management of critically ill patients with sepsis.

METHODS: A group of 14 experts from anesthesiology and critical care, infectious diseases, internal medicine, pulmonology, clinical microbiology, laboratory medicine, clinical pharmacology and methodology provided expert opinion through a modified Delphi process, after a comprehensive literature review.

RESULTS: The appropriateness of use of PCT in terms of diagnosis, prognosis and antimicrobial stewardship was assessed for different scenarios or settings such us management of infection in the emergency department, regular wards, surgical wards or in the intensive care unit. Similarly, appropriateness and timing of PCT measurement were evaluated. All the process consisted in three Delphi rounds.

CONCLUSIONS: PCT use is appropriate in algorithms for antibiotic de-escalation and discontinuation. In this case, reproducible, high sensitive assays should be used. However, initiation or escalation of antibiotic therapy in specific scenarios, including acute respiratory infections, should not be based solely on PCT serum levels. Clinical and radiological findings, evaluation of severity of illness and of patient's characteristics should be taken into proper account in order to correctly interpret PCT results.

Original languageEnglish
Pages (from-to)1223-1229
Number of pages7
JournalClinical Chemistry and Laboratory Medicine
Volume56
Issue number8
DOIs
Publication statusPublished - Jul 26 2018

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Calcitonin
Anti-Bacterial Agents
Therapeutics
Critical Care
Medicine
Infectious Disease Medicine
Anesthesiology
Microbiology
Intensive care units
Pulmonary Medicine
Clinical Pharmacology
Expert Testimony
Biomarkers
Internal Medicine
Bacterial Infections
Critical Illness
Respiratory Tract Infections
Intensive Care Units
Hospital Emergency Service
Assays

Cite this

Bartoletti, M., Antonelli, M., Bruno Blasi, F. A., Casagranda, I., Chieregato, A., Fumagalli, R., ... Pea, F. (2018). Procalcitonin-guided antibiotic therapy: an expert consensus. Clinical Chemistry and Laboratory Medicine, 56(8), 1223-1229. https://doi.org/10.1515/cclm-2018-0259

Procalcitonin-guided antibiotic therapy : an expert consensus. / Bartoletti, Michele; Antonelli, Massimo; Bruno Blasi, Francesco Arturo; Casagranda, Ivo; Chieregato, Arturo; Fumagalli, Roberto; Girardis, Massimo; Pieralli, Filippo; Plebani, Mario; Rossolini, Gian Maria; Sartelli, Massimo; Viaggi, Bruno; Viale, Pierluigi; Viscoli, Claudio; Pea, Federico.

In: Clinical Chemistry and Laboratory Medicine, Vol. 56, No. 8, 26.07.2018, p. 1223-1229.

Research output: Contribution to journalArticle

Bartoletti, M, Antonelli, M, Bruno Blasi, FA, Casagranda, I, Chieregato, A, Fumagalli, R, Girardis, M, Pieralli, F, Plebani, M, Rossolini, GM, Sartelli, M, Viaggi, B, Viale, P, Viscoli, C & Pea, F 2018, 'Procalcitonin-guided antibiotic therapy: an expert consensus', Clinical Chemistry and Laboratory Medicine, vol. 56, no. 8, pp. 1223-1229. https://doi.org/10.1515/cclm-2018-0259
Bartoletti M, Antonelli M, Bruno Blasi FA, Casagranda I, Chieregato A, Fumagalli R et al. Procalcitonin-guided antibiotic therapy: an expert consensus. Clinical Chemistry and Laboratory Medicine. 2018 Jul 26;56(8):1223-1229. https://doi.org/10.1515/cclm-2018-0259
Bartoletti, Michele ; Antonelli, Massimo ; Bruno Blasi, Francesco Arturo ; Casagranda, Ivo ; Chieregato, Arturo ; Fumagalli, Roberto ; Girardis, Massimo ; Pieralli, Filippo ; Plebani, Mario ; Rossolini, Gian Maria ; Sartelli, Massimo ; Viaggi, Bruno ; Viale, Pierluigi ; Viscoli, Claudio ; Pea, Federico. / Procalcitonin-guided antibiotic therapy : an expert consensus. In: Clinical Chemistry and Laboratory Medicine. 2018 ; Vol. 56, No. 8. pp. 1223-1229.
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AU - Chieregato, Arturo

AU - Fumagalli, Roberto

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AU - Rossolini, Gian Maria

AU - Sartelli, Massimo

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N2 - BACKGROUND: Procalcitonin (PCT) is a useful biomarker of bacterial infection and its use is associated to reduced duration of antibiotic therapy in the setting of intensive care medicine. To address the need of practical guidance for the use of PCT in various clinical settings, a group of experts was invited to participate at a consensus process with the aims of defining the rationale for appropriate use of PCT and for improving the management of critically ill patients with sepsis.METHODS: A group of 14 experts from anesthesiology and critical care, infectious diseases, internal medicine, pulmonology, clinical microbiology, laboratory medicine, clinical pharmacology and methodology provided expert opinion through a modified Delphi process, after a comprehensive literature review.RESULTS: The appropriateness of use of PCT in terms of diagnosis, prognosis and antimicrobial stewardship was assessed for different scenarios or settings such us management of infection in the emergency department, regular wards, surgical wards or in the intensive care unit. Similarly, appropriateness and timing of PCT measurement were evaluated. All the process consisted in three Delphi rounds.CONCLUSIONS: PCT use is appropriate in algorithms for antibiotic de-escalation and discontinuation. In this case, reproducible, high sensitive assays should be used. However, initiation or escalation of antibiotic therapy in specific scenarios, including acute respiratory infections, should not be based solely on PCT serum levels. Clinical and radiological findings, evaluation of severity of illness and of patient's characteristics should be taken into proper account in order to correctly interpret PCT results.

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