Il PROCARDIS: un approccio attuale allo studio della genetica dell'infarto miocardico.

Translated title of the contribution: PROCARDIS: A current approach to the study of the genetics of myocardial infarct

S. Barlera, B. D. Chiodini, M. G. Franzosi, G. Tognoni

Research output: Contribution to journalArticle

Abstract

Coronary artery disease is a complex and multifactorial pathology. Although the environmental component of coronary artery disease has been thoroughly investigated and is hence well known, knowledge about the genetic factors implicated in this disease is still scarce. Technological advances and the fact that the Human Genome Project has almost been completed allow the application of approaches that were not feasible few years ago to the genetic investigation of complex diseases. The aim of the PROCARDIS study is to identify new susceptibility genes of precocious coronary artery disease, through a genome-wide screen applying statistical methods of linkage analysis followed by a family-based association study. The originality of PROCARDIS lies in the fact that it is an international multicenter study. This allows recruitment of a very large number of individuals so that the population size, considered up to now unachievable, is adequate for the aims of the study.

Translated title of the contributionPROCARDIS: A current approach to the study of the genetics of myocardial infarct
Original languageItalian
Pages (from-to)997-1004
Number of pages8
JournalItalian Heart Journal
Volume2
Issue number9 Suppl
Publication statusPublished - Sep 2001

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'PROCARDIS: A current approach to the study of the genetics of myocardial infarct'. Together they form a unique fingerprint.

  • Cite this

    Barlera, S., Chiodini, B. D., Franzosi, M. G., & Tognoni, G. (2001). Il PROCARDIS: un approccio attuale allo studio della genetica dell'infarto miocardico. Italian Heart Journal, 2(9 Suppl), 997-1004.