Processed Meat and Risk of Renal Cell and Bladder Cancers

Valentina Rosato, Eva Negri, Diego Serraino, Maurizio Montella, Massimo Libra, Pagona Lagiou, Gaetano Facchini, Monica Ferraroni, Adriano Decarli, Carlo La Vecchia

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Abstract

We assessed the association of processed meat intake with the risk of renal cell carcinoma (RCC) and bladder cancer. We used data from two Italian hospital-based case-control studies, including 1,115 RCC cases and 2,582 controls, and 1,417 bladder cancer cases and 1,732 controls. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) with unconditional logistic regression models, adjusted for major confounders. The median consumption of processed meat in cases and controls was around 2 portions/week (50 g/portion). The ORs for a daily 10 g increment of processed meat was 0.89 (95% CI 0.84-0.94) for RCC and 1.00 (95% CI 0.94-1.06) for bladder cancer. The OR for the highest vs. the lowest consumption was 0.80 (95% CI 0.66-0.96) for RCC and 0.98 (95% CI 0.80-1.21) for bladder cancer. The ORs were consistent in strata of various covariates. For bladder cancer, however, a significant 23% excess risk was found in women (95% CI 1.03-1.47) for a daily increase of 10 g, significantly heterogeneous from the risk recorded in men (OR 0.96, 95% CI 0.90-1.02). The inconsistent results between men and women and the absence of association in both sexes combined indicate that the apparent association between processed meat and bladder cancer in women is unlikely to be causal.

Original languageEnglish
Pages (from-to)418-424
Number of pages7
JournalNutrition and Cancer
Volume70
Issue number3
DOIs
Publication statusPublished - Apr 2018

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Renal Cell Carcinoma
Urinary Bladder Neoplasms
Meat
Confidence Intervals
Odds Ratio
Logistic Models
Case-Control Studies

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Processed Meat and Risk of Renal Cell and Bladder Cancers. / Rosato, Valentina; Negri, Eva; Serraino, Diego; Montella, Maurizio; Libra, Massimo; Lagiou, Pagona; Facchini, Gaetano; Ferraroni, Monica; Decarli, Adriano; La Vecchia, Carlo.

In: Nutrition and Cancer, Vol. 70, No. 3, 04.2018, p. 418-424.

Research output: Contribution to journalArticle

Rosato, V, Negri, E, Serraino, D, Montella, M, Libra, M, Lagiou, P, Facchini, G, Ferraroni, M, Decarli, A & La Vecchia, C 2018, 'Processed Meat and Risk of Renal Cell and Bladder Cancers', Nutrition and Cancer, vol. 70, no. 3, pp. 418-424. https://doi.org/10.1080/01635581.2018.1445764
Rosato, Valentina ; Negri, Eva ; Serraino, Diego ; Montella, Maurizio ; Libra, Massimo ; Lagiou, Pagona ; Facchini, Gaetano ; Ferraroni, Monica ; Decarli, Adriano ; La Vecchia, Carlo. / Processed Meat and Risk of Renal Cell and Bladder Cancers. In: Nutrition and Cancer. 2018 ; Vol. 70, No. 3. pp. 418-424.
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AB - We assessed the association of processed meat intake with the risk of renal cell carcinoma (RCC) and bladder cancer. We used data from two Italian hospital-based case-control studies, including 1,115 RCC cases and 2,582 controls, and 1,417 bladder cancer cases and 1,732 controls. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) with unconditional logistic regression models, adjusted for major confounders. The median consumption of processed meat in cases and controls was around 2 portions/week (50 g/portion). The ORs for a daily 10 g increment of processed meat was 0.89 (95% CI 0.84-0.94) for RCC and 1.00 (95% CI 0.94-1.06) for bladder cancer. The OR for the highest vs. the lowest consumption was 0.80 (95% CI 0.66-0.96) for RCC and 0.98 (95% CI 0.80-1.21) for bladder cancer. The ORs were consistent in strata of various covariates. For bladder cancer, however, a significant 23% excess risk was found in women (95% CI 1.03-1.47) for a daily increase of 10 g, significantly heterogeneous from the risk recorded in men (OR 0.96, 95% CI 0.90-1.02). The inconsistent results between men and women and the absence of association in both sexes combined indicate that the apparent association between processed meat and bladder cancer in women is unlikely to be causal.

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