Processed meat and selected hormone-related cancers

Valentina Rosato, Eva Negri, Fabio Parazzini, Diego Serraino, Maurizio Montella, Monica Ferraroni, Adriano Decarli, Carlo La Vecchia

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To assess and quantify the association between processed meat consumption and cancers of the breast, endometrium, ovary, and prostate. Methods: Data were derived from an integrated network of hospital-based case-control studies conducted between 1982 and 2006 in various Italian areas. These studies included 5981 cases of cancer of the breast, 992 of the endometrium, 2002 of the ovary, 1582 of the prostate, and a total of 16 394 controls with data on processed meat. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by unconditional multiple logistic regression models, adjusted for major recognized confounders for each cancer site. Results: The median consumption of processed meat in this population was 2 portions per wk in each cancer-specific cases, controls, and overall, corresponding to 100 g/wk. The OR for the highest (≥20 g/d) compared with lowest (<10 g/d) category of processed meat consumption was 1.16 (95% CI 1.06–1.28) for breast, 1.31 (95% CI 1.07–1.60) for endometrial, 1.49 (95% CI 1.30–1.71) for ovarian, and 0.89 (95% CI 0.74–1.07) for prostate cancer. Conclusion: In this case-control study, we found some excess risks of high processed meat consumption with female hormone-related cancers. Conversely, no association with prostate cancer was found in men.

Original languageEnglish
Pages (from-to)17-23
Number of pages7
JournalNutrition
Volume49
DOIs
Publication statusPublished - May 1 2018

Fingerprint

Meat
Hormones
Confidence Intervals
Neoplasms
Case-Control Studies
Prostate
Ovary
Prostatic Neoplasms
Logistic Models
Odds Ratio
Breast Neoplasms
Endometrial Neoplasms
Endometrium
Breast
Population

Keywords

  • Breast
  • Cancer
  • Diet
  • Endometrium
  • Meat
  • Ovary
  • Prostate

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Processed meat and selected hormone-related cancers. / Rosato, Valentina; Negri, Eva; Parazzini, Fabio; Serraino, Diego; Montella, Maurizio; Ferraroni, Monica; Decarli, Adriano; La Vecchia, Carlo.

In: Nutrition, Vol. 49, 01.05.2018, p. 17-23.

Research output: Contribution to journalArticle

Rosato, Valentina ; Negri, Eva ; Parazzini, Fabio ; Serraino, Diego ; Montella, Maurizio ; Ferraroni, Monica ; Decarli, Adriano ; La Vecchia, Carlo. / Processed meat and selected hormone-related cancers. In: Nutrition. 2018 ; Vol. 49. pp. 17-23.
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abstract = "Objective: To assess and quantify the association between processed meat consumption and cancers of the breast, endometrium, ovary, and prostate. Methods: Data were derived from an integrated network of hospital-based case-control studies conducted between 1982 and 2006 in various Italian areas. These studies included 5981 cases of cancer of the breast, 992 of the endometrium, 2002 of the ovary, 1582 of the prostate, and a total of 16 394 controls with data on processed meat. Odds ratios (ORs) and 95{\%} confidence intervals (CIs) were calculated by unconditional multiple logistic regression models, adjusted for major recognized confounders for each cancer site. Results: The median consumption of processed meat in this population was 2 portions per wk in each cancer-specific cases, controls, and overall, corresponding to 100 g/wk. The OR for the highest (≥20 g/d) compared with lowest (<10 g/d) category of processed meat consumption was 1.16 (95{\%} CI 1.06–1.28) for breast, 1.31 (95{\%} CI 1.07–1.60) for endometrial, 1.49 (95{\%} CI 1.30–1.71) for ovarian, and 0.89 (95{\%} CI 0.74–1.07) for prostate cancer. Conclusion: In this case-control study, we found some excess risks of high processed meat consumption with female hormone-related cancers. Conversely, no association with prostate cancer was found in men.",
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