Abstract

OBJECTIVE: To assess and quantify the association between processed meat consumption and cancers of the breast, endometrium, ovary, and prostate.

METHODS: Data were derived from an integrated network of hospital-based case-control studies conducted between 1982 and 2006 in various Italian areas. These studies included 5981 cases of cancer of the breast, 992 of the endometrium, 2002 of the ovary, 1582 of the prostate, and a total of 16 394 controls with data on processed meat. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by unconditional multiple logistic regression models, adjusted for major recognized confounders for each cancer site.

RESULTS: The median consumption of processed meat in this population was 2 portions per wk in each cancer-specific cases, controls, and overall, corresponding to 100 g/wk. The OR for the highest (≥20 g/d) compared with lowest (<10 g/d) category of processed meat consumption was 1.16 (95% CI 1.06-1.28) for breast, 1.31 (95% CI 1.07-1.60) for endometrial, 1.49 (95% CI 1.30-1.71) for ovarian, and 0.89 (95% CI 0.74-1.07) for prostate cancer.

CONCLUSION: In this case-control study, we found some excess risks of high processed meat consumption with female hormone-related cancers. Conversely, no association with prostate cancer was found in men.

Original languageEnglish
Pages (from-to)17-23
Number of pages7
JournalNutrition
Volume49
DOIs
Publication statusPublished - May 2018

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Meat
Hormones
Confidence Intervals
Neoplasms
Case-Control Studies
Prostate
Ovary
Prostatic Neoplasms
Logistic Models
Odds Ratio
Breast Neoplasms
Endometrial Neoplasms
Endometrium
Breast
Population

Cite this

Processed meat and selected hormone-related cancers. / Rosato, Valentina; Negri, Eva; Parazzini, Fabio; Serraino, Diego; Montella, Maurizio; Ferraroni, Monica; Decarli, Adriano; La Vecchia, Carlo.

In: Nutrition, Vol. 49, 05.2018, p. 17-23.

Research output: Contribution to journalArticle

Rosato, Valentina ; Negri, Eva ; Parazzini, Fabio ; Serraino, Diego ; Montella, Maurizio ; Ferraroni, Monica ; Decarli, Adriano ; La Vecchia, Carlo. / Processed meat and selected hormone-related cancers. In: Nutrition. 2018 ; Vol. 49. pp. 17-23.
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abstract = "OBJECTIVE: To assess and quantify the association between processed meat consumption and cancers of the breast, endometrium, ovary, and prostate.METHODS: Data were derived from an integrated network of hospital-based case-control studies conducted between 1982 and 2006 in various Italian areas. These studies included 5981 cases of cancer of the breast, 992 of the endometrium, 2002 of the ovary, 1582 of the prostate, and a total of 16 394 controls with data on processed meat. Odds ratios (ORs) and 95{\%} confidence intervals (CIs) were calculated by unconditional multiple logistic regression models, adjusted for major recognized confounders for each cancer site.RESULTS: The median consumption of processed meat in this population was 2 portions per wk in each cancer-specific cases, controls, and overall, corresponding to 100 g/wk. The OR for the highest (≥20 g/d) compared with lowest (<10 g/d) category of processed meat consumption was 1.16 (95{\%} CI 1.06-1.28) for breast, 1.31 (95{\%} CI 1.07-1.60) for endometrial, 1.49 (95{\%} CI 1.30-1.71) for ovarian, and 0.89 (95{\%} CI 0.74-1.07) for prostate cancer.CONCLUSION: In this case-control study, we found some excess risks of high processed meat consumption with female hormone-related cancers. Conversely, no association with prostate cancer was found in men.",
author = "Valentina Rosato and Eva Negri and Fabio Parazzini and Diego Serraino and Maurizio Montella and Monica Ferraroni and Adriano Decarli and {La Vecchia}, Carlo",
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T1 - Processed meat and selected hormone-related cancers

AU - Rosato, Valentina

AU - Negri, Eva

AU - Parazzini, Fabio

AU - Serraino, Diego

AU - Montella, Maurizio

AU - Ferraroni, Monica

AU - Decarli, Adriano

AU - La Vecchia, Carlo

N1 - Copyright © 2017 Elsevier Inc. All rights reserved.

PY - 2018/5

Y1 - 2018/5

N2 - OBJECTIVE: To assess and quantify the association between processed meat consumption and cancers of the breast, endometrium, ovary, and prostate.METHODS: Data were derived from an integrated network of hospital-based case-control studies conducted between 1982 and 2006 in various Italian areas. These studies included 5981 cases of cancer of the breast, 992 of the endometrium, 2002 of the ovary, 1582 of the prostate, and a total of 16 394 controls with data on processed meat. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by unconditional multiple logistic regression models, adjusted for major recognized confounders for each cancer site.RESULTS: The median consumption of processed meat in this population was 2 portions per wk in each cancer-specific cases, controls, and overall, corresponding to 100 g/wk. The OR for the highest (≥20 g/d) compared with lowest (<10 g/d) category of processed meat consumption was 1.16 (95% CI 1.06-1.28) for breast, 1.31 (95% CI 1.07-1.60) for endometrial, 1.49 (95% CI 1.30-1.71) for ovarian, and 0.89 (95% CI 0.74-1.07) for prostate cancer.CONCLUSION: In this case-control study, we found some excess risks of high processed meat consumption with female hormone-related cancers. Conversely, no association with prostate cancer was found in men.

AB - OBJECTIVE: To assess and quantify the association between processed meat consumption and cancers of the breast, endometrium, ovary, and prostate.METHODS: Data were derived from an integrated network of hospital-based case-control studies conducted between 1982 and 2006 in various Italian areas. These studies included 5981 cases of cancer of the breast, 992 of the endometrium, 2002 of the ovary, 1582 of the prostate, and a total of 16 394 controls with data on processed meat. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by unconditional multiple logistic regression models, adjusted for major recognized confounders for each cancer site.RESULTS: The median consumption of processed meat in this population was 2 portions per wk in each cancer-specific cases, controls, and overall, corresponding to 100 g/wk. The OR for the highest (≥20 g/d) compared with lowest (<10 g/d) category of processed meat consumption was 1.16 (95% CI 1.06-1.28) for breast, 1.31 (95% CI 1.07-1.60) for endometrial, 1.49 (95% CI 1.30-1.71) for ovarian, and 0.89 (95% CI 0.74-1.07) for prostate cancer.CONCLUSION: In this case-control study, we found some excess risks of high processed meat consumption with female hormone-related cancers. Conversely, no association with prostate cancer was found in men.

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DO - 10.1016/j.nut.2017.10.025

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JF - Nutrition International

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