Processing Magnetic resonance image features with one-class support vector machines investigation of the autism spectrum disorder heterogeneity

Ilaria Gori, Alessia Giuliano, Piernicola Oliva, Michela Tosetti, Filippo Muratori, Sara Calderoni, Alessandra Retico

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Support Vector Machine (SVM) classifiers are widely used to analyse features extracted from brain MRI data to identify useful biomarkers of pathology in several disease conditions. They are trained to distinguish patients from healthy control subjects by making a binary classification of image features extracted by image processing algorithms. This task is particularly challenging when dealing with psychiatric disorders, as the reported neuroanatomical alterations are often very small and quite un-replicated within different studies. Subtle signs of pathology are difficult to catch especially in extremely heterogeneous conditions such as Autism Spectrum Disorders (ASD). We propose the use of the One-Class Classification (OCC) or Data Description method that, in contrast with two-class classification, is based on a description of one class of objects only. Then, new examples are tested for their similarity to the examples of this target class, end eventually considered as outliers. The application of the OCC to features extracted from brain MRI of children affected by ASD and control subjects demonstrated that a common pattern of features characterize the ASD population.

Original languageEnglish
Title of host publicationBIOIMAGING 2016 - 3rd International Conference on Bioimaging, Proceedings; Part of 9th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2016
PublisherSciTePress
Pages111-117
Number of pages7
ISBN (Print)9789897581700
Publication statusPublished - 2016
Event3rd International Conference on Bioimaging, BIOIMAGING 2016 - Part of 9th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2016 - Rome, Italy
Duration: Feb 21 2016Feb 23 2016

Other

Other3rd International Conference on Bioimaging, BIOIMAGING 2016 - Part of 9th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2016
Country/TerritoryItaly
CityRome
Period2/21/162/23/16

Keywords

  • Autism spectrum disorders
  • Brain magnetic resonance imaging (MRI)
  • Feature classification
  • Image processing
  • One-class support vector machine

ASJC Scopus subject areas

  • Biomedical Engineering
  • Electrical and Electronic Engineering

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