Processualita dell'epilessia del lobo temporale

A seizure-induced clinical progression of Temporal Lobe Epilepsy (TLE) is suggested by clinical and experimental data. TLE is characterized by seizures that begin in the second half of the first decade of life and are initially easily controlled by antiepileptic medication but become subsequently refractory. Mesial temporal sclerosis (MTS) is often associated with TLE. Experimental studies show that a sustained epileptic activity involving the hippocampal structures may per se induce degeneration- regeneration phenomena resulting in a sprouting of the mossy fibers that can account for persistent epileptogenic phenomena. The relevance of such a seizure-induced epileptogenic mechanism for the human TLE should be investigated by controlled studies.