Abstract
Cerebral amyloid angiopathy-related inflammation (CAA-ri), a rare form of vasculitis associated with amyloid-β (Aβ) deposition in vessel walls, has been proposed as a spontaneous human model of the amyloid-related imaging abnormalities (ARIA) occurring after anti-Aβ immunotherapy for the treatment of Alzheimer's disease (AD). We describe a case of a patient with biopsy-proven CAA-ri and prodromal AD, confirmed by means of neuropsychological examination after 20 months follow-up, presenting with ARIA and high levels of cerebrospinal fluid anti-Aβ autoantibodies. This case further supports the analogies between the inflammatory response driven by anti-Aβ immunotherapy and that spontaneously occurring in CAA-ri.
| Original language | English |
|---|---|
| Pages (from-to) | 363-367 |
| Number of pages | 5 |
| Journal | Journal of Alzheimer's Disease |
| Volume | 45 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2015 |
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Keywords
- Alzheimer's disease
- amyloid-related imaging abnormalities
- anti-Aβ autoantibodies
- cerebral amyloid angiopathy
- cerebral amyloid angiopathy-related inflammation
- subarachnoid hemorrhage
ASJC Scopus subject areas
- Psychiatry and Mental health
- Geriatrics and Gerontology
- Clinical Psychology
- Medicine(all)
Cite this
Prodromal Alzheimer's Disease Presenting as Cerebral Amyloid Angiopathy-Related Inflammation with Spontaneous Amyloid-Related Imaging Abnormalities and High Cerebrospinal Fluid Anti-Aβ Autoantibodies. / Boncoraglio, Giorgio B.; Piazza, Fabrizio; Savoiardo, Mario; Farina, Laura; Difrancesco, Jacopo C.; Prioni, Sara; Tagliavini, Fabrizio; Parati, Eugenio A.; Giaccone, Giorgio.
In: Journal of Alzheimer's Disease, Vol. 45, No. 2, 2015, p. 363-367.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prodromal Alzheimer's Disease Presenting as Cerebral Amyloid Angiopathy-Related Inflammation with Spontaneous Amyloid-Related Imaging Abnormalities and High Cerebrospinal Fluid Anti-Aβ Autoantibodies
AU - Boncoraglio, Giorgio B.
AU - Piazza, Fabrizio
AU - Savoiardo, Mario
AU - Farina, Laura
AU - Difrancesco, Jacopo C.
AU - Prioni, Sara
AU - Tagliavini, Fabrizio
AU - Parati, Eugenio A.
AU - Giaccone, Giorgio
PY - 2015
Y1 - 2015
N2 - Cerebral amyloid angiopathy-related inflammation (CAA-ri), a rare form of vasculitis associated with amyloid-β (Aβ) deposition in vessel walls, has been proposed as a spontaneous human model of the amyloid-related imaging abnormalities (ARIA) occurring after anti-Aβ immunotherapy for the treatment of Alzheimer's disease (AD). We describe a case of a patient with biopsy-proven CAA-ri and prodromal AD, confirmed by means of neuropsychological examination after 20 months follow-up, presenting with ARIA and high levels of cerebrospinal fluid anti-Aβ autoantibodies. This case further supports the analogies between the inflammatory response driven by anti-Aβ immunotherapy and that spontaneously occurring in CAA-ri.
AB - Cerebral amyloid angiopathy-related inflammation (CAA-ri), a rare form of vasculitis associated with amyloid-β (Aβ) deposition in vessel walls, has been proposed as a spontaneous human model of the amyloid-related imaging abnormalities (ARIA) occurring after anti-Aβ immunotherapy for the treatment of Alzheimer's disease (AD). We describe a case of a patient with biopsy-proven CAA-ri and prodromal AD, confirmed by means of neuropsychological examination after 20 months follow-up, presenting with ARIA and high levels of cerebrospinal fluid anti-Aβ autoantibodies. This case further supports the analogies between the inflammatory response driven by anti-Aβ immunotherapy and that spontaneously occurring in CAA-ri.
KW - Alzheimer's disease
KW - amyloid-related imaging abnormalities
KW - anti-Aβ autoantibodies
KW - cerebral amyloid angiopathy
KW - cerebral amyloid angiopathy-related inflammation
KW - subarachnoid hemorrhage
UR - http://www.scopus.com/inward/record.url?scp=84925347817&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84925347817&partnerID=8YFLogxK
U2 - 10.3233/JAD-142376
DO - 10.3233/JAD-142376
M3 - Article
C2 - 25537009
AN - SCOPUS:84925347817
VL - 45
SP - 363
EP - 367
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
SN - 1387-2877
IS - 2
ER -