TY - JOUR
T1 - Prodromal Alzheimer's Disease Presenting as Cerebral Amyloid Angiopathy-Related Inflammation with Spontaneous Amyloid-Related Imaging Abnormalities and High Cerebrospinal Fluid Anti-Aβ Autoantibodies
AU - Boncoraglio, Giorgio B.
AU - Piazza, Fabrizio
AU - Savoiardo, Mario
AU - Farina, Laura
AU - Difrancesco, Jacopo C.
AU - Prioni, Sara
AU - Tagliavini, Fabrizio
AU - Parati, Eugenio A.
AU - Giaccone, Giorgio
PY - 2015
Y1 - 2015
N2 - Cerebral amyloid angiopathy-related inflammation (CAA-ri), a rare form of vasculitis associated with amyloid-β (Aβ) deposition in vessel walls, has been proposed as a spontaneous human model of the amyloid-related imaging abnormalities (ARIA) occurring after anti-Aβ immunotherapy for the treatment of Alzheimer's disease (AD). We describe a case of a patient with biopsy-proven CAA-ri and prodromal AD, confirmed by means of neuropsychological examination after 20 months follow-up, presenting with ARIA and high levels of cerebrospinal fluid anti-Aβ autoantibodies. This case further supports the analogies between the inflammatory response driven by anti-Aβ immunotherapy and that spontaneously occurring in CAA-ri.
AB - Cerebral amyloid angiopathy-related inflammation (CAA-ri), a rare form of vasculitis associated with amyloid-β (Aβ) deposition in vessel walls, has been proposed as a spontaneous human model of the amyloid-related imaging abnormalities (ARIA) occurring after anti-Aβ immunotherapy for the treatment of Alzheimer's disease (AD). We describe a case of a patient with biopsy-proven CAA-ri and prodromal AD, confirmed by means of neuropsychological examination after 20 months follow-up, presenting with ARIA and high levels of cerebrospinal fluid anti-Aβ autoantibodies. This case further supports the analogies between the inflammatory response driven by anti-Aβ immunotherapy and that spontaneously occurring in CAA-ri.
KW - Alzheimer's disease
KW - amyloid-related imaging abnormalities
KW - anti-Aβ autoantibodies
KW - cerebral amyloid angiopathy
KW - cerebral amyloid angiopathy-related inflammation
KW - subarachnoid hemorrhage
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U2 - 10.3233/JAD-142376
DO - 10.3233/JAD-142376
M3 - Article
C2 - 25537009
AN - SCOPUS:84925347817
VL - 45
SP - 363
EP - 367
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
SN - 1387-2877
IS - 2
ER -