Prodromal Alzheimer's Disease Presenting as Cerebral Amyloid Angiopathy-Related Inflammation with Spontaneous Amyloid-Related Imaging Abnormalities and High Cerebrospinal Fluid Anti-Aβ Autoantibodies

Giorgio B. Boncoraglio; Fabrizio Piazza; Mario Savoiardo; Laura Farina; Jacopo C. Difrancesco; Sara Prioni; Fabrizio Tagliavini; Eugenio A. Parati; Giorgio Giaccone

doi:10.3233/JAD-142376

Prodromal Alzheimer's Disease Presenting as Cerebral Amyloid Angiopathy-Related Inflammation with Spontaneous Amyloid-Related Imaging Abnormalities and High Cerebrospinal Fluid Anti-Aβ Autoantibodies

Giorgio B. Boncoraglio, Fabrizio Piazza, Mario Savoiardo, Laura Farina, Jacopo C. Difrancesco, Sara Prioni, Fabrizio Tagliavini, Eugenio A. Parati, Giorgio Giaccone

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article › peer-review

Abstract

Cerebral amyloid angiopathy-related inflammation (CAA-ri), a rare form of vasculitis associated with amyloid-β (Aβ) deposition in vessel walls, has been proposed as a spontaneous human model of the amyloid-related imaging abnormalities (ARIA) occurring after anti-Aβ immunotherapy for the treatment of Alzheimer's disease (AD). We describe a case of a patient with biopsy-proven CAA-ri and prodromal AD, confirmed by means of neuropsychological examination after 20 months follow-up, presenting with ARIA and high levels of cerebrospinal fluid anti-Aβ autoantibodies. This case further supports the analogies between the inflammatory response driven by anti-Aβ immunotherapy and that spontaneously occurring in CAA-ri.

Original language	English
Pages (from-to)	363-367
Number of pages	5
Journal	Journal of Alzheimer's Disease
Volume	45
Issue number	2
DOIs	https://doi.org/10.3233/JAD-142376
Publication status	Published - 2015

Keywords

Alzheimer's disease
amyloid-related imaging abnormalities
anti-Aβ autoantibodies
cerebral amyloid angiopathy
cerebral amyloid angiopathy-related inflammation
subarachnoid hemorrhage

ASJC Scopus subject areas

Psychiatry and Mental health
Geriatrics and Gerontology
Clinical Psychology
Medicine(all)

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10.3233/JAD-142376

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Boncoraglio, G. B., Piazza, F., Savoiardo, M., Farina, L., Difrancesco, J. C., Prioni, S., Tagliavini, F., Parati, E. A., & Giaccone, G. (2015). Prodromal Alzheimer's Disease Presenting as Cerebral Amyloid Angiopathy-Related Inflammation with Spontaneous Amyloid-Related Imaging Abnormalities and High Cerebrospinal Fluid Anti-Aβ Autoantibodies. Journal of Alzheimer's Disease, 45(2), 363-367. https://doi.org/10.3233/JAD-142376

Prodromal Alzheimer's Disease Presenting as Cerebral Amyloid Angiopathy-Related Inflammation with Spontaneous Amyloid-Related Imaging Abnormalities and High Cerebrospinal Fluid Anti-Aβ Autoantibodies. / Boncoraglio, Giorgio B.; Piazza, Fabrizio; Savoiardo, Mario; Farina, Laura ; Difrancesco, Jacopo C.; Prioni, Sara; Tagliavini, Fabrizio ; Parati, Eugenio A.; Giaccone, Giorgio.

In: Journal of Alzheimer's Disease, Vol. 45, No. 2, 2015, p. 363-367.

Research output: Contribution to journal › Article › peer-review

Boncoraglio, GB, Piazza, F, Savoiardo, M, Farina, L , Difrancesco, JC, Prioni, S, Tagliavini, F , Parati, EA & Giaccone, G 2015, 'Prodromal Alzheimer's Disease Presenting as Cerebral Amyloid Angiopathy-Related Inflammation with Spontaneous Amyloid-Related Imaging Abnormalities and High Cerebrospinal Fluid Anti-Aβ Autoantibodies', Journal of Alzheimer's Disease, vol. 45, no. 2, pp. 363-367. https://doi.org/10.3233/JAD-142376

Boncoraglio, Giorgio B. ; Piazza, Fabrizio ; Savoiardo, Mario ; Farina, Laura ; Difrancesco, Jacopo C. ; Prioni, Sara ; Tagliavini, Fabrizio ; Parati, Eugenio A. ; Giaccone, Giorgio. / Prodromal Alzheimer's Disease Presenting as Cerebral Amyloid Angiopathy-Related Inflammation with Spontaneous Amyloid-Related Imaging Abnormalities and High Cerebrospinal Fluid Anti-Aβ Autoantibodies. In: Journal of Alzheimer's Disease. 2015 ; Vol. 45, No. 2. pp. 363-367.

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abstract = "Cerebral amyloid angiopathy-related inflammation (CAA-ri), a rare form of vasculitis associated with amyloid-β (Aβ) deposition in vessel walls, has been proposed as a spontaneous human model of the amyloid-related imaging abnormalities (ARIA) occurring after anti-Aβ immunotherapy for the treatment of Alzheimer's disease (AD). We describe a case of a patient with biopsy-proven CAA-ri and prodromal AD, confirmed by means of neuropsychological examination after 20 months follow-up, presenting with ARIA and high levels of cerebrospinal fluid anti-Aβ autoantibodies. This case further supports the analogies between the inflammatory response driven by anti-Aβ immunotherapy and that spontaneously occurring in CAA-ri.",

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