Production and characterization of monoclonal antibodies specific for different epitopes of human tenascin

Enrica Balza; Annalisa Siri; Marco Ponassi; Fabio Caocci; Auli Linnala; Ismo Virtanen; Luciano Zardi

doi:10.1016/0014-5793(93)80479-E

Production and characterization of monoclonal antibodies specific for different epitopes of human tenascin

Enrica Balza, Annalisa Siri, Marco Ponassi, Fabio Caocci, Auli Linnala, Ismo Virtanen, Luciano Zardi

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

We have obtained and characterized 11 monoclonal antibodies (mAbs) specific for different domains of human tenascin (TN). Five of these mAbs reacted with epitopes contained in the TN area that undergoes alternative splicing and are thus able to recognize specific TN isoforms. These mAbs are a useful tool to study the expression and distribution of TN and its different isoforms in normal and pathological tissues.

Original language	English
Pages (from-to)	39-43
Number of pages	5
Journal	FEBS Letters
Volume	332
Issue number	1-2
DOIs	https://doi.org/10.1016/0014-5793(93)80479-E
Publication status	Published - Oct 11 1993

Keywords

Monoclonal antibody
Tenascin

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

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10.1016/0014-5793(93)80479-E

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abstract = "We have obtained and characterized 11 monoclonal antibodies (mAbs) specific for different domains of human tenascin (TN). Five of these mAbs reacted with epitopes contained in the TN area that undergoes alternative splicing and are thus able to recognize specific TN isoforms. These mAbs are a useful tool to study the expression and distribution of TN and its different isoforms in normal and pathological tissues.",

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AU - Balza, Enrica

AU - Siri, Annalisa

AU - Ponassi, Marco

AU - Caocci, Fabio

AU - Linnala, Auli

AU - Virtanen, Ismo

AU - Zardi, Luciano

PY - 1993/10/11

Y1 - 1993/10/11

N2 - We have obtained and characterized 11 monoclonal antibodies (mAbs) specific for different domains of human tenascin (TN). Five of these mAbs reacted with epitopes contained in the TN area that undergoes alternative splicing and are thus able to recognize specific TN isoforms. These mAbs are a useful tool to study the expression and distribution of TN and its different isoforms in normal and pathological tissues.

AB - We have obtained and characterized 11 monoclonal antibodies (mAbs) specific for different domains of human tenascin (TN). Five of these mAbs reacted with epitopes contained in the TN area that undergoes alternative splicing and are thus able to recognize specific TN isoforms. These mAbs are a useful tool to study the expression and distribution of TN and its different isoforms in normal and pathological tissues.

KW - Monoclonal antibody

KW - Tenascin

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IS - 1-2

ER -

Production and characterization of monoclonal antibodies specific for different epitopes of human tenascin

Abstract

Keywords

ASJC Scopus subject areas

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