Production and characterization of monoclonal antibodies specific for different epitopes of human tenascin

Enrica Balza, Annalisa Siri, Marco Ponassi, Fabio Caocci, Auli Linnala, Ismo Virtanen, Luciano Zardi

Research output: Contribution to journalArticle

Abstract

We have obtained and characterized 11 monoclonal antibodies (mAbs) specific for different domains of human tenascin (TN). Five of these mAbs reacted with epitopes contained in the TN area that undergoes alternative splicing and are thus able to recognize specific TN isoforms. These mAbs are a useful tool to study the expression and distribution of TN and its different isoforms in normal and pathological tissues.

Original languageEnglish
Pages (from-to)39-43
Number of pages5
JournalFEBS Letters
Volume332
Issue number1-2
DOIs
Publication statusPublished - Oct 11 1993

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Keywords

  • Monoclonal antibody
  • Tenascin

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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