Production of an enterotoxin different from toxin A by Clostridium difficile

Marina Giuliano, Fiorella Piemonte, Paola Mastrantonio Gianfrilli

Research output: Contribution to journalArticlepeer-review


Clostridium difficile has been demonstrated to produce at least two toxins: an enterotoxin (toxin A) which elicits haemorrhagoc fluid accumulation in the rabbit ileal loop (RIL) test and a potent cytotoxin (toxin B). We report the isolation of an enterotoxic factor inducing a positive response in the RIL test without haemorrhage. This factor was separated by ion-exchange chromatography and its molecular weight, as estimated by SDS-polyacrylamide gel electrophoresis, was about 45 000.

Original languageEnglish
Pages (from-to)191-194
Number of pages4
JournalFEMS Microbiology Letters
Issue number2-3
Publication statusPublished - 1988


  • Clostridium difficile
  • Enterotoxin

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Microbiology


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