Production of fertile offspring from genetically infertile male mice

Ryuzo Yanagimachi, Teruhiko Wakayama, Hidefumi Kishikawa, Gian Maria Fimia, Lucia Monaco, Paolo Sassone-Corsi

Research output: Contribution to journalArticlepeer-review


A number of recessive autosomal genes cause male infertility. Male mice homozygous for the blind-sterile (bs/bs) and quaking-sterile (qk/qk) gene mutations are sterile, because they either do not produce any spermatozoa or produce only a few abnormal spermatozoa. Mice lacking the cyclic AMP responsive-element modulator gene are sterile due to failure of spermiogenesis. All these mice, however, are able to produce fertile offspring when their spermatozoa or round spermatids are injected into oocytes of normal females. This implies that genetic and epigenetic elements necessary for syngamy and embryonic development are established in round spermatids and spermatozoa of these animals, even though their spermatogenic cells are destined to die (bs/bs and qk/qk) or are programmed to undergo apoptosis (cyclic AMP responsive-element modulator-null) without becoming functional spermatozoa.

Original languageEnglish
Pages (from-to)1691-1695
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number6
Publication statusPublished - Feb 10 2004

ASJC Scopus subject areas

  • General
  • Genetics

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