Mononuclear phagocytes have been shown to produce a monokine termed LAF (Lymphocyte-Activating-Factor) or Interleukin 1, when stimulated by several agents (e. g. Ab-Ag complexes, bacterial endotoxin). This soluble factor acts both directly stimulating lymphocyte-DNA-synthesis and, more clearly, increasing the proliferative response of thymocytes to lectins. In this paper, we investigate the possibility that the wear particles from biomaterials, used in constructing artificial prostheses for orthopedic surgery, can influence mononuclear phagoctye production of LAF effective on mouse thymocytes.
|Title of host publication||Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium|
|Editors||James M. Anderson|
|Publisher||Soc for Biomaterials|
|Number of pages||1|
|Publication status||Published - 1984|
ASJC Scopus subject areas
- Materials Science(all)