PRODUCTION OF LAF (LYMPHOCYTE-ACTIVATING-FACTOR) BY MONONUCLEAR PHAGOCYTES ACTIVATED WITH POWDERED BIOMATERIALS.

A. Pizzoferrato, G. Ciapetti, S. Stea

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Mononuclear phagocytes have been shown to produce a monokine termed LAF (Lymphocyte-Activating-Factor) or Interleukin 1, when stimulated by several agents (e. g. Ab-Ag complexes, bacterial endotoxin). This soluble factor acts both directly stimulating lymphocyte-DNA-synthesis and, more clearly, increasing the proliferative response of thymocytes to lectins. In this paper, we investigate the possibility that the wear particles from biomaterials, used in constructing artificial prostheses for orthopedic surgery, can influence mononuclear phagoctye production of LAF effective on mouse thymocytes.

Original languageEnglish
Title of host publicationTransactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium
EditorsJames M. Anderson
PublisherSoc for Biomaterials
Pages312
Number of pages1
Volume7
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Materials Science(all)

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