Production of prostacyclin and fibrinolysis modulators by endothelial cells cultured in the presence of polyethylene terephthalate

E. Cenni, G. Ciapetti, D. Cavedagna, A. Di Leo, A. Pizzoferrato

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was the evaluation of the in vitro production of prostacyclin, and of tissue plasminogen activator (tPA) and its inhibitor, PAI-1, by human endothelial cells cultured in the presence of polyethylene terephthalate (PET). After a 48 h contact between the cells and the polymer, the concentration of 6-keto-PGF, a stable metabolite of prostacyclin, tPA, and PAI-1, was assayed on the supernatants. Contact of the endothelial cells with PET produced a highly significant reduction of 6-keto-PGF with respect to control cultures. Tissue plasminogen activator concentration in the supernatants of the cultures in contact with the material was similar to that observed in the controls, while PAI-1 production was significantly reduced. It can be concluded that the contact between endothelial cells and PET determines a reduction in the platelet aggregability and an increase of the fibrinolytic activity due to a decrease in PAI-1, while tPA concentration remains unchanged.

Original languageEnglish
Pages (from-to)1161-1164
Number of pages4
JournalJournal of Biomedical Materials Research
Volume27
Issue number9
Publication statusPublished - Sep 1993

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

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