Productive infection of HUVEC by HHV-8 is associated with changes compatible with angiogenic transformations.

C. Foglieni, S. Scabini, D. Belloni, F. Broccolo, P. Lusso, M. S. Malnati, E. Ferrero

Research output: Contribution to journalArticlepeer-review

Abstract

Kaposi's Sarcoma (KS) is an angioproliferative disease associated with human herpesvirus 8 (HHV-8) infection. We have characterized the morphologic and phenotypic modifications of HUVEC in a model of productive HHV-8 infection. HHV-8 replication was associated with ultra-structural changes, flattened soma and a loss of marginal folds and intercellular contacts, and morphologic features, spindle cell conversion and cordon-like structures formation. Phenotypic changes observed on cordon-like structures included partial loss and redistribution of CD31/PECAM-1 and VE-cadherin, uPAR up-regulation and de novo expression of CD13/APN. Such changes demonstrate the induction, in HUVEC, of an angiogenic profile. Most of these findings are directly linked to HHV-8-encoded proteins expression, suggesting that HHV-8 itself may participate to the initial steps of the angiogenic transformation in KS.

Original languageEnglish
Pages (from-to)273-284
Number of pages12
JournalEuropean journal of histochemistry : EJH
Volume49
Issue number3
Publication statusPublished - Jul 2005

ASJC Scopus subject areas

  • Cell Biology
  • Anatomy
  • Animal Science and Zoology
  • Developmental Biology

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