Productive infection of HUVEC by HHV-8 is associated with changes compatible with angiogenic transformations.

C. Foglieni, S. Scabini, D. Belloni, F. Broccolo, P. Lusso, M. S. Malnati, E. Ferrero

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Kaposi's Sarcoma (KS) is an angioproliferative disease associated with human herpesvirus 8 (HHV-8) infection. We have characterized the morphologic and phenotypic modifications of HUVEC in a model of productive HHV-8 infection. HHV-8 replication was associated with ultra-structural changes, flattened soma and a loss of marginal folds and intercellular contacts, and morphologic features, spindle cell conversion and cordon-like structures formation. Phenotypic changes observed on cordon-like structures included partial loss and redistribution of CD31/PECAM-1 and VE-cadherin, uPAR up-regulation and de novo expression of CD13/APN. Such changes demonstrate the induction, in HUVEC, of an angiogenic profile. Most of these findings are directly linked to HHV-8-encoded proteins expression, suggesting that HHV-8 itself may participate to the initial steps of the angiogenic transformation in KS.

Original languageEnglish
Pages (from-to)273-284
Number of pages12
JournalEuropean journal of histochemistry : EJH
Volume49
Issue number3
Publication statusPublished - Jul 2005

Fingerprint

Human herpesvirus 8
Human Herpesvirus 8
Herpesviridae Infections
Infection
infection
Kaposi's Sarcoma
sarcoma
CD31 Antigens
cadherins
Carisoprodol
Up-Regulation
protein synthesis
Proteins

ASJC Scopus subject areas

  • Cell Biology
  • Anatomy
  • Animal Science and Zoology
  • Developmental Biology

Cite this

Productive infection of HUVEC by HHV-8 is associated with changes compatible with angiogenic transformations. / Foglieni, C.; Scabini, S.; Belloni, D.; Broccolo, F.; Lusso, P.; Malnati, M. S.; Ferrero, E.

In: European journal of histochemistry : EJH, Vol. 49, No. 3, 07.2005, p. 273-284.

Research output: Contribution to journalArticle

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AU - Foglieni, C.

AU - Scabini, S.

AU - Belloni, D.

AU - Broccolo, F.

AU - Lusso, P.

AU - Malnati, M. S.

AU - Ferrero, E.

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AB - Kaposi's Sarcoma (KS) is an angioproliferative disease associated with human herpesvirus 8 (HHV-8) infection. We have characterized the morphologic and phenotypic modifications of HUVEC in a model of productive HHV-8 infection. HHV-8 replication was associated with ultra-structural changes, flattened soma and a loss of marginal folds and intercellular contacts, and morphologic features, spindle cell conversion and cordon-like structures formation. Phenotypic changes observed on cordon-like structures included partial loss and redistribution of CD31/PECAM-1 and VE-cadherin, uPAR up-regulation and de novo expression of CD13/APN. Such changes demonstrate the induction, in HUVEC, of an angiogenic profile. Most of these findings are directly linked to HHV-8-encoded proteins expression, suggesting that HHV-8 itself may participate to the initial steps of the angiogenic transformation in KS.

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