Profile of cerebrospinal fluid and serum cytokines in patients with relapsing-remitting multiple sclerosis: A correlation with clinical activity

P. B. Carrieri, V. Provitera, T. De Rosa, G. Tartaglia, F. Gorga, O. Perrella

Research output: Contribution to journalArticle

Abstract

Levels of tumor necrosis factor (TNF)-α, granulocyte macrophage-colony stimulating factor (GM-CSF), interleukin (IL)-10 and transforming growth factor (TGF)-β in cerebrospinal fluid (CSF) and serum of 29 patients with multiple sclerosis (MS) of the relapsing-remitting type and of 20 controls with other non inflammatory neurological diseases were studied. Sixteen patients were in the active phase of disease and 13 in remission. In CSF, higher IL-10 and TGF-β concentrations were found in patients with a stable phase of MS, while in the active phase there were elevated levels of TNF-α and GM-CSF. These results suggest that a different cytokine pattern could be probably involved in the pathogenesis of relapsing-remitting MS.

Original languageEnglish
Pages (from-to)373-382
Number of pages10
JournalImmunopharmacology and Immunotoxicology
Volume20
Issue number3
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Immunology
  • Pharmacology
  • Toxicology

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