Profiling of specific gene expression pathways in peripheral cells from prodromal Alzheimer's disease patients

Maria Serpente, Chiara Fenoglio, Sara Maria Giulia Cioffi, Emanuela Oldoni, Marina Arcaro, Andrea Arighi, Giorgio Giulio Fumagalli, Laura Ghezzi, Elio Scarpini, Daniela Galimberti

Research output: Contribution to journalArticle

Abstract

Herein, we performed a gene expression profiling in a cohort of 10 mild cognitive impairment (MCI), subdivided, according to the analysis of cerebrospinal fluid biomarkers, in prodromal Alzheimer's disease (AD) and non-AD MCI, as compared with 27 AD patients and 24 controls, in order to detect early gene expression alterations. We observed a significant upregulation of insulin (INS) and INS Receptor (INSR) expression levels in AD both prodromal and fully symptomatic, as compared with controls, but not in MCI subjects. Our results suggest an early dysregulation of INS and INSR in AD pathogenesis and pave the way to a possible utility of these transcripts as peripheral biomarkers.

Original languageEnglish
Pages (from-to)1289-1294
Number of pages6
JournalJournal of Alzheimer's Disease
Volume61
Issue number4
DOIs
Publication statusPublished - Jan 1 2018

Keywords

  • Gene expression
  • insulin
  • insulin receptor
  • peripheral biomarkers
  • prodromal Alzheimer's disease

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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