Progesterone modulates the expression of HDL binding sites in human skin fibroblasts

A. Corsini, A. Granata, F. Bernini, F. M. Maggi, R. Fumagalli, A. L. Catapano

Research output: Contribution to journalArticle

Abstract

The aim of this work was to study the effects of progesterone on the expression of high density lipoprotein binding sites by cultured human skin fibroblasts. At concentrations ranging between 10-6- and 10-4 M the hormone showed a dose-dependent induction of the HDL binding sites. The effect was maximal at 48 h. The increased HDL binding was only due to an up-regulation of binding sites, without changes of the apparent Kd. This effect was not related to changes of cellular cholesterol content, and was not affected by inhibition of protein synthesis. These data suggest that the expression of binding sites for HDL can be modulated via a mechanism that does not depend upon cellular cholesterol content.

Original languageEnglish
Pages (from-to)107-113
Number of pages7
JournalAtherosclerosis
Volume74
Issue number1-2
DOIs
Publication statusPublished - 1988

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Keywords

  • Binding sites
  • Cholesterol
  • High density lipoproteins
  • Progesterone

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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