TY - JOUR
T1 - Progesterone receptor gene (PROGINS) polymorphism correlates with late onset of migraine
AU - Palmirotta, Raffaele
AU - Barbanti, Piero
AU - Ialongo, Cristiano
AU - De Marchis, Maria Laura
AU - Alessandroni, Jhessica
AU - Egeo, Gabriella
AU - Aurilia, Cinzia
AU - Fofi, Luisa
AU - Valente, Maria Giovanna
AU - Ferroni, Patrizia
AU - Della-Morte, David
AU - Guadagni, Fiorella
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Progesterone influences central neuronal excitability, a key event in migraine pathophysiology. Progesterone receptor gene (PGR) rs1042838 (G/T - Val660Leu) variant is indicative of PROGINS haplotype and associated to a reduced PGR activity. With the aim of investigating whether any type of association existed between this genetic variant and migraine pathophysiology, genotyping was performed in 380 consecutive migraine patients and 185 age-, sex-, and race-ethnicity-matched healthy controls from Interinstitutional Multidisciplinary BioBank (BioBIM) of IRCCS San Raffaele Pisana, Rome, Italy. rs1042838 genotypes did not correlate with demographics or clinical migraine features. However, TT (Leu) genotype was significantly associated with a later age of migraine onset: Patients affected by migraine with aura showed a linear relationship between copy number of the T allele carried by the individual and the age of migraine onset. Our data suggest that the PROGINS PGR polymorphism does not directly predispose to migraine but significantly delays migraine onset probably via a reduction in brain neuronal excitability.
AB - Progesterone influences central neuronal excitability, a key event in migraine pathophysiology. Progesterone receptor gene (PGR) rs1042838 (G/T - Val660Leu) variant is indicative of PROGINS haplotype and associated to a reduced PGR activity. With the aim of investigating whether any type of association existed between this genetic variant and migraine pathophysiology, genotyping was performed in 380 consecutive migraine patients and 185 age-, sex-, and race-ethnicity-matched healthy controls from Interinstitutional Multidisciplinary BioBank (BioBIM) of IRCCS San Raffaele Pisana, Rome, Italy. rs1042838 genotypes did not correlate with demographics or clinical migraine features. However, TT (Leu) genotype was significantly associated with a later age of migraine onset: Patients affected by migraine with aura showed a linear relationship between copy number of the T allele carried by the individual and the age of migraine onset. Our data suggest that the PROGINS PGR polymorphism does not directly predispose to migraine but significantly delays migraine onset probably via a reduction in brain neuronal excitability.
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U2 - 10.1089/dna.2014.2534
DO - 10.1089/dna.2014.2534
M3 - Article
C2 - 25494303
AN - SCOPUS:84923068792
VL - 34
SP - 208
EP - 212
JO - DNA and Cell Biology
JF - DNA and Cell Biology
SN - 1044-5498
IS - 3
ER -