Progesterone receptor immunoreactivity in minute meningothelioid nodules of the lung

Research output: Contribution to journalArticle

Abstract

Meningothelioid nodules (MNs) are not uncommon lesions of the pulmonary interstitium composed of monomorphic round to spindle cells, likely reactive in nature. Their origin is unsettled, though a derivation from arachnoid-like cells in conditions of perturbed perfusion of the pulmonary tissue has been proposed. Here we confirm the consistent occurrence of intense progesterone-receptor immunoreactivity in MNs fortuitously detected in surgical specimens of lung carcinomas. This finding corroborates the view that these proliferations exhibit arachnoid cell-like differentiation and suggests a role for sex-steroid hormones in the control of their growth.

Original languageEnglish
Pages (from-to)543-546
Number of pages4
JournalVirchows Archiv
Volume440
Issue number5
DOIs
Publication statusPublished - 2002

Keywords

  • Immunohistochemistry
  • Lung
  • Meningothelioid nodule
  • Progesterone receptors

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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