Progesterone sensitive Interferon-γ producing cells detected by ELISpot assay in autoimmune progesterone dermatitis

A. Cristaudo, V. Bordignon, F. Palamara, M. De Rocco, M. Pietravalle, M. Picardo

Research output: Contribution to journalArticle

Abstract

Autoimmune progesterone dermatitis (APD) is a rare cutaneous disorder, characterized by recurrent polymorphous cutaneous and mucosal manifestations. It is considered to be caused by a hypersensitive reaction to endogenous progesterone. However, in vitro T-cell activity to this hormone has been described in few patients. Here we report the case of a 30-year-old woman with recurrent pruritic erythematous, and erythema multiforme-like eruptions localized to the genital area. Positive cutaneous reaction to intradermal progesterone injection suggested the diagnosis of APD. The analysis of cellular immune response to progesterone, investigated by the ELISpot assay, showed a significantly higher level of Interferon-γ (IFN-γ) producing cells in this patient compared with a control group comprising five asymptomatic women in the luteal phase of the menstrual cycle. Our results suggest that the ELISpot technique, together with clinical evaluations and assessment of allergies, could be useful in the diagnosis of APD.

Original languageEnglish
Pages (from-to)439-441
Number of pages3
JournalClinical and Experimental Dermatology
Volume32
Issue number4
DOIs
Publication statusPublished - Jul 2007

ASJC Scopus subject areas

  • Dermatology

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