Progestogen-only contraceptive pill compared with combined oral contraceptive in the treatment of pain symptoms caused by endometriosis in patients with migraine without aura

Matteo Morotti, Valentino Remorgida, Pier Luigi Venturini, Simone Ferrero

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Evaluate patient satisfaction at 6-month treatment in women with symptomatic rectovaginal endometriosis and migraine without aura with (progestogen-only contraceptive pill, POP versus sequential combined oral contraceptives, COC) Study Design: A patient preference trial including 144 women (82 in the group COC and 62 in the group POP). Main outcome measure was the degree of patient satisfaction by using a Likert scale. Secondary objectives were to evaluate differences in endometriosis-related pain and changes in migraine features during the treatment. Results: In group POP, 38/62 women (61.2%) were satisfied or very satisfied after treatment, compared to 31/82 women (37.8%) in group COC (p = 0.005). The intensity of chronic pelvic pain and dyspareunia significantly decreased at 6-month treatment in both the groups. At 6-month treatment, the number of migraine attacks was lower than at baseline in group POP (p = 0.002), while it was not reduced in group COC (p = 0.521). The intensity of migraine attacks was significantly different between baseline and 6-month treatment in group POP (p <0.001) but not in group COC (p = 0.078). Conclusions: POP is better tolerated than COC and it seems to ameliorate migraine attacks compared to COC in symptomatic patients with rectovaginal endometriosis and migraine without aura. Both drugs efficaciously relieve endometriosis-related pain symptoms. This study supports the use of the POP in women with rectovaginal endometriosis and coexisting migraine without aura.

Original languageEnglish
Pages (from-to)63-68
Number of pages6
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Volume179
DOIs
Publication statusPublished - 2014

Keywords

  • Combined oral contraceptive
  • Endometriosis
  • Migraine without aura
  • Pain
  • Progestins

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine
  • Medicine(all)

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