Prognoses for head and neck cancers in Europe diagnosed in 1995-1999: A population-based study

G. Zigon, F. Berrino, G. Gatta, M. J. Sánchez, B. van Dijk, E. van Eycken, S. Francisci

Research output: Contribution to journalArticle

Abstract

Background: Head and neck cancers are a heterogeneous group of malignancies, affecting various sites and subsites, with differing prognoses. The aim of this study was to analyse survival for European head and neck cancer patients in populations covered by population-based cancer registries (CRs), in relation to tumour subsite as prognostic factor. Patients and methods: We analysed 51 912 adult head and neck cancer cases (36 322 mouth-pharynx and 15 590 larynx) diagnosed from 1995 to 1999 and archived by 45 CRs in 20 countries participating in EUROCARE-4. Five-year age-standardised relative survival was estimated for mouth-pharynx and larynx sites by sex and country. Relative survival was modelled to provide estimates of relative excess risks (RERs) of death by country, adjusted for confounding factors. Results: A large but site-variable proportion of tumours were incompletely specified. Five-year age-standardised relative survival was low in Slovakia and high in The Netherlands. Adjustment for subsite reduced RERs of death for most countries; 5-year relative survival increased from 1990-1994 to 1995-1999 for all subsites, while betweencountry differences in survival narrowed. Conclusion: Differences in subsite distribution explain a considerable part of the survival differences for head and neck cancers, however, incomplete/inaccurate subsite reporting complicate interpretation.

Original languageEnglish
Pages (from-to)165-174
Number of pages10
JournalAnnals of Oncology
Volume22
Issue number1
DOIs
Publication statusPublished - 2011

Fingerprint

Head and Neck Neoplasms
Survival
Population
Neoplasms
Larynx
Pharynx
Registries
Mouth
Slovakia
Survival Analysis
Netherlands

Keywords

  • Cancer registries
  • Head and neck cancers
  • Relative survival
  • Subsite localisation

ASJC Scopus subject areas

  • Oncology
  • Hematology

Cite this

Zigon, G., Berrino, F., Gatta, G., Sánchez, M. J., van Dijk, B., van Eycken, E., & Francisci, S. (2011). Prognoses for head and neck cancers in Europe diagnosed in 1995-1999: A population-based study. Annals of Oncology, 22(1), 165-174. https://doi.org/10.1093/annonc/mdq306

Prognoses for head and neck cancers in Europe diagnosed in 1995-1999 : A population-based study. / Zigon, G.; Berrino, F.; Gatta, G.; Sánchez, M. J.; van Dijk, B.; van Eycken, E.; Francisci, S.

In: Annals of Oncology, Vol. 22, No. 1, 2011, p. 165-174.

Research output: Contribution to journalArticle

Zigon, G, Berrino, F, Gatta, G, Sánchez, MJ, van Dijk, B, van Eycken, E & Francisci, S 2011, 'Prognoses for head and neck cancers in Europe diagnosed in 1995-1999: A population-based study', Annals of Oncology, vol. 22, no. 1, pp. 165-174. https://doi.org/10.1093/annonc/mdq306
Zigon, G. ; Berrino, F. ; Gatta, G. ; Sánchez, M. J. ; van Dijk, B. ; van Eycken, E. ; Francisci, S. / Prognoses for head and neck cancers in Europe diagnosed in 1995-1999 : A population-based study. In: Annals of Oncology. 2011 ; Vol. 22, No. 1. pp. 165-174.
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