Prognosis and cure of long-term cancer survivors: A population-based estimation

Luigino Dal Maso, Chiara Panato, Stefano Guzzinati, Diego Serraino, Silvia Francisci, Laura Botta, Riccardo Capocaccia, Andrea Tavilla, Anna Gigli, Emanuele Crocetti, Massimo Rugge, Giovanna Tagliabue, Rosa Angela Filiberti, Giuliano Carrozzi, Maria Michiara, Stefano Ferretti, Rosaria Cesaraccio, Rosario Tumino, Fabio Falcini, Fabrizio StracciAntonietta Torrisi, Guido Mazzoleni, Mario Fusco, Stefano Rosso, Francesco Tisano, Anna Clara Fanetti, Giovanna Maria Sini, Carlotta Buzzoni, Roberta De Angelis, AIRTUM Working group

Research output: Contribution to journalArticlepeer-review


BACKGROUND: Increasing evidence of cure for some neoplasms has emerged in recent years. The study aimed to estimate population-based indicators of cancer cure. METHODS: Information on more than half a million cancer patients aged 15-74 years collected by population-based Italian cancer registries and mixture cure models were used to estimate the life expectancy of fatal tumors (LEFT), proportions of patients with similar death rates of the general population (cure fraction), and time to reach 5-year conditional relative survival (CRS) >90% or 95% (time to cure). RESULTS: Between 1990 and 2000, the median LEFT increased >1 year for breast (from 8.1 to 9.4 years) and prostate cancers (from 5.2 to 7.4 years). Median LEFT in 1990 was >5 years for testicular cancers (5.8) and Hodgkin lymphoma (6.3) below 45 years of age. In both sexes, it was ≤0.5 years for pancreatic cancers and NHL in 1990 and in 2000. The cure fraction showed a 10% increase between 1990 and 2000. It was 95% for thyroid cancer in women, 94% for testis, 75% for prostate, 67% for breast cancers, and 95% was 90% was reached in 15 years. CONCLUSIONS: The study findings confirmed that several cancer types are curable. Became aware of the possibility of cancer cure has relevant clinical and social impacts.
Original languageEnglish
Pages (from-to)4497-4507
Number of pages11
JournalCancer Medicine
Issue number9
Publication statusPublished - Aug 2019


  • Italy
  • cancer cure
  • population-based cancer registries
  • prevalence
  • survival


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