Prognosis based on primary breast carcinoma instead of pathological nodal status

S. Menard, R. Bufalino, F. Rilke, N. Cascinelli, U. Veronesi, M. I. Colnaghi

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

In breast cancer patients, prognostic information required to plan post-surgical therapy is obtained mainly through axillary dissection. This study was designed to establish a new prognostic score based solely on parameters of the primary tumour as an alternative to axillary surgery in assessing prognosis. Eight different prognostic factors, including menopausal status, tumour size, grading, lymphatic invasion, desmoplasia, necrosis, c-erbB-2 and laminin receptor expression, were evaluated retrospectively on a large series of primary breast carcinoma patients. From multivariate analysis, four independent parameters were selected and examined, alone and in combination, for their prognostic potential. These parameters were used to generate a prognostic score that was analysed retrospectively in 467 N0-N1a patients to determine its predictive value for survival. The score, which includes variables such as tumour size, grading, laminin receptor and c-erbB-2 overexpression, was established based on the number of negative prognostic factors: score I refers to cases in which all four parameters reflect a good prognosis, scores 2 and 3 refer to tumours in which, respectively, one or two of the four parameters reflect a poor prognosis, whereas score 4 refers to tumours with three or four poor prognosis factors. Analysis of the overall survival of the four score groups shows that patients with score 1 tumours (22% of the total) had the best prognosis with a 15 year survival of 82%, patients with score 2 and 3 had an intermediate prognosis, whereas score 4 patients had the poorest prognosis with a 15 year survival of only 38%. Moreover, survival in the N + score 1 cases was found to be longer than that in the total N + patients. Our data suggest that the primary tumour score provides more reliable prognostic information than pathological nodal status, and that axillary dissection can be avoided in a large number of patients.

Original languageEnglish
Pages (from-to)709-712
Number of pages4
JournalBritish Journal of Cancer
Volume70
Issue number4
Publication statusPublished - 1994

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Breast Neoplasms
Laminin Receptors
Survival
Neoplasm Grading
Neoplasms
Dissection
ErbB-2 Receptor
Survival Analysis
Necrosis
Multivariate Analysis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Menard, S., Bufalino, R., Rilke, F., Cascinelli, N., Veronesi, U., & Colnaghi, M. I. (1994). Prognosis based on primary breast carcinoma instead of pathological nodal status. British Journal of Cancer, 70(4), 709-712.

Prognosis based on primary breast carcinoma instead of pathological nodal status. / Menard, S.; Bufalino, R.; Rilke, F.; Cascinelli, N.; Veronesi, U.; Colnaghi, M. I.

In: British Journal of Cancer, Vol. 70, No. 4, 1994, p. 709-712.

Research output: Contribution to journalArticle

Menard, S, Bufalino, R, Rilke, F, Cascinelli, N, Veronesi, U & Colnaghi, MI 1994, 'Prognosis based on primary breast carcinoma instead of pathological nodal status', British Journal of Cancer, vol. 70, no. 4, pp. 709-712.
Menard S, Bufalino R, Rilke F, Cascinelli N, Veronesi U, Colnaghi MI. Prognosis based on primary breast carcinoma instead of pathological nodal status. British Journal of Cancer. 1994;70(4):709-712.
Menard, S. ; Bufalino, R. ; Rilke, F. ; Cascinelli, N. ; Veronesi, U. ; Colnaghi, M. I. / Prognosis based on primary breast carcinoma instead of pathological nodal status. In: British Journal of Cancer. 1994 ; Vol. 70, No. 4. pp. 709-712.
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