Prognosis of chronic myelomonocytic leukemia

L. Catalano, S. Improta, M. De Laurentiis, S. Molica, I. Majolino, P. Musto, A. Fragasso, S. De Placido, B. Rotoli

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background. Cytopenia caused by ineffective hematopoiesis and monocyte overproduction coexist in GMML, providing grounds for discussion to supporters of a dysplastic versus a proliferative identity for GMML. Follow- up information from a large series of patients may contribute to clarifying the position of this infrequent disease. Methods. We analyzed data from 77 patients followed in five institutions. Thirty-two variables were studied for their influence on survival and on progression to acute leukemia by univariate and multivariate analysis. For some parameters, we performed a quartile analysis to reveal a possible non-monotonic influence on survival. Results. Median survival was 17 months. Evolution to acute leukemia (ANLL) occurred in 11 patients (14%) within a median time of 8 months. Multivariate analysis assigned a poorer prognosis to patients presenting with thrombocytopenia, anemia and leukocytosis. Thrombocytopenia and the presence of circulating blasts were risk factors for transformation to ANLL, while raised serum aspartate transaminase at diagnosis seemed to be associated with a lower probability of blastic evolution. The Bournemouth score for CMML proved to be a valid tool for predicting survival but not acute transformation. Conclusions. CMML is a severe disease. The prognostic independence of cytopenia (anemia, thrombocytopenia) and leukocytosis underlines the coexistence of aspects typical of myelodysplastic and myeloproliferative syndromes.

Original languageEnglish
Pages (from-to)324-329
Number of pages6
JournalHaematologica
Volume81
Issue number4
Publication statusPublished - 1996

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Leukemia, Myelomonocytic, Chronic
Thrombocytopenia
Survival
Leukocytosis
Acute Myeloid Leukemia
Anemia
Leukemia
Multivariate Analysis
Myelodysplastic Syndromes
Hematopoiesis
Aspartate Aminotransferases
Monocytes
Serum

Keywords

  • Chronic myelomonocytic leukemia
  • Myelodyplastic syndromes
  • Myeloproliferative syndromes

ASJC Scopus subject areas

  • Hematology

Cite this

Catalano, L., Improta, S., De Laurentiis, M., Molica, S., Majolino, I., Musto, P., ... Rotoli, B. (1996). Prognosis of chronic myelomonocytic leukemia. Haematologica, 81(4), 324-329.

Prognosis of chronic myelomonocytic leukemia. / Catalano, L.; Improta, S.; De Laurentiis, M.; Molica, S.; Majolino, I.; Musto, P.; Fragasso, A.; De Placido, S.; Rotoli, B.

In: Haematologica, Vol. 81, No. 4, 1996, p. 324-329.

Research output: Contribution to journalArticle

Catalano, L, Improta, S, De Laurentiis, M, Molica, S, Majolino, I, Musto, P, Fragasso, A, De Placido, S & Rotoli, B 1996, 'Prognosis of chronic myelomonocytic leukemia', Haematologica, vol. 81, no. 4, pp. 324-329.
Catalano L, Improta S, De Laurentiis M, Molica S, Majolino I, Musto P et al. Prognosis of chronic myelomonocytic leukemia. Haematologica. 1996;81(4):324-329.
Catalano, L. ; Improta, S. ; De Laurentiis, M. ; Molica, S. ; Majolino, I. ; Musto, P. ; Fragasso, A. ; De Placido, S. ; Rotoli, B. / Prognosis of chronic myelomonocytic leukemia. In: Haematologica. 1996 ; Vol. 81, No. 4. pp. 324-329.
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AU - De Laurentiis, M.

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AU - Musto, P.

AU - Fragasso, A.

AU - De Placido, S.

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