Prognosi dell'epilessia in pazienti adolescenti e adulti di nuova diagnosi afferenti a due centri per l'epilessia: Probabilità di remissione e principali predittori prognostici

Translated title of the contribution: Prognosis of epilepsy in newly diagnosed adolescents and adults referred to two epilepsy centers. Probability of remission and risk factors

G. Boero, G. Bogliun, A. Del Felice, B. Frigeni, A. De Palo, G. De Agazio, N. Specchio, A. La Neve, M. Radaelli, E. Beghi, L. M. Specchio

Research output: Contribution to journalArticlepeer-review

Abstract

About a third of patients diagnosed with epilepsy will not be fully controlled with antiepileptic drugs. The aim of this study is to assess, in a population of newly diagnosed patients treated with antiepileptic drugs, the rates of seizure remission in general and with reference to various prognostic factors. The study included patients with newly diagnosed epilepsy seen in two tertiary Italian centers (Monza and Bari). The cumulative probability of 2 year remission in the study population was calculated using Kaplan-Meier survival curves. Differences were tested with the Log-rank test. Multivariate analysis was performed with the Cox's proportional hazard function. The sample included 368 cases (men 185; women 183) aged 3 to 84 years (> 16 years 83%) followed for 25,815 months/person. 194 patients were enrolled in Monza and 174 in Bari. The cumulative probability of completing a 2 year remission period at 2 and 5 years was 42% and 56%, respectively. Remission rates were significantly higher in male (p = 0.043) and in patients with a family history of epilepsy (p=0.05). The results confirmed the good prognosis of epilepsy and above all of the genetic-determined ones.

Translated title of the contributionPrognosis of epilepsy in newly diagnosed adolescents and adults referred to two epilepsy centers. Probability of remission and risk factors
Original languageItalian
Pages (from-to)39-42
Number of pages4
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number121-122
Publication statusPublished - Jul 2003

ASJC Scopus subject areas

  • Clinical Neurology

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