TY - JOUR
T1 - Prognosis of myasthenia gravis
T2 - A multicenter follow-up study of 844 patients
AU - Beghi, Ettore
AU - Antozzi, Carlo
AU - Batocchi, Anna P.
AU - Cornelio, Ferdinando
AU - Cosi, Vittore
AU - Evoli, Amelia
AU - Lombardi, Mariella
AU - Mantegazza, Renato
AU - Monticelli, M. Luisa
AU - Piccolo, Giovanni
AU - Tonali, Pietro
AU - Trevisan, Daniela
AU - Zarrelli, Michele
PY - 1991
Y1 - 1991
N2 - The prognosis of myasthenia gravis (MG) was assessed retrospectively using life-table analysis in 844 patients followed up for a mean period of 5 years in 3 major Italian centers. The chance of achieving at least a 1-year remission after treatment withdrawal (complete remission) was assessed as a specific end-point in the whole population and in selected subgroups with reference to the principal prognostic variables. The cumulative probability of complete remission was 1% by 1 year, 8% by 3 years. 13% by 5 years, and 21% by 10 years. The only variables correlated to the chance of complete remission were younger age at onset of MG, lower severity of symptoms at onset and nadir, and shorter disease duration at diagnosis. In addition, thymectomy and early surgery seemed to influence the chance of remission. Other factors (including the presence of thymoma) did not significantly influence the outcome of the disease.
AB - The prognosis of myasthenia gravis (MG) was assessed retrospectively using life-table analysis in 844 patients followed up for a mean period of 5 years in 3 major Italian centers. The chance of achieving at least a 1-year remission after treatment withdrawal (complete remission) was assessed as a specific end-point in the whole population and in selected subgroups with reference to the principal prognostic variables. The cumulative probability of complete remission was 1% by 1 year, 8% by 3 years. 13% by 5 years, and 21% by 10 years. The only variables correlated to the chance of complete remission were younger age at onset of MG, lower severity of symptoms at onset and nadir, and shorter disease duration at diagnosis. In addition, thymectomy and early surgery seemed to influence the chance of remission. Other factors (including the presence of thymoma) did not significantly influence the outcome of the disease.
KW - Multicenter follow-up study
KW - Myasthenia gravis
KW - Prognosis
KW - Surgery
KW - Therapy
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U2 - 10.1016/0022-510X(91)90260-E
DO - 10.1016/0022-510X(91)90260-E
M3 - Article
C2 - 1802969
AN - SCOPUS:0026327429
VL - 106
SP - 213
EP - 220
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
SN - 0022-510X
IS - 2
ER -