Prognosis of myasthenia gravis: A multicenter follow-up study of 844 patients

Ettore Beghi, Carlo Antozzi, Anna P. Batocchi, Ferdinando Cornelio, Vittore Cosi, Amelia Evoli, Mariella Lombardi, Renato Mantegazza, M. Luisa Monticelli, Giovanni Piccolo, Pietro Tonali, Daniela Trevisan, Michele Zarrelli

Research output: Contribution to journalArticle

Abstract

The prognosis of myasthenia gravis (MG) was assessed retrospectively using life-table analysis in 844 patients followed up for a mean period of 5 years in 3 major Italian centers. The chance of achieving at least a 1-year remission after treatment withdrawal (complete remission) was assessed as a specific end-point in the whole population and in selected subgroups with reference to the principal prognostic variables. The cumulative probability of complete remission was 1% by 1 year, 8% by 3 years. 13% by 5 years, and 21% by 10 years. The only variables correlated to the chance of complete remission were younger age at onset of MG, lower severity of symptoms at onset and nadir, and shorter disease duration at diagnosis. In addition, thymectomy and early surgery seemed to influence the chance of remission. Other factors (including the presence of thymoma) did not significantly influence the outcome of the disease.

Original languageEnglish
Pages (from-to)213-220
Number of pages8
JournalJournal of the Neurological Sciences
Volume106
Issue number2
DOIs
Publication statusPublished - 1991

Keywords

  • Multicenter follow-up study
  • Myasthenia gravis
  • Prognosis
  • Surgery
  • Therapy

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

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  • Cite this

    Beghi, E., Antozzi, C., Batocchi, A. P., Cornelio, F., Cosi, V., Evoli, A., Lombardi, M., Mantegazza, R., Monticelli, M. L., Piccolo, G., Tonali, P., Trevisan, D., & Zarrelli, M. (1991). Prognosis of myasthenia gravis: A multicenter follow-up study of 844 patients. Journal of the Neurological Sciences, 106(2), 213-220. https://doi.org/10.1016/0022-510X(91)90260-E