Prognosis of myasthenia gravis: A multicenter follow-up study of 844 patients

Ettore Beghi; Carlo Antozzi; Anna P. Batocchi; Ferdinando Cornelio; Vittore Cosi; Amelia Evoli; Mariella Lombardi; Renato Mantegazza; M. Luisa Monticelli; Giovanni Piccolo; Pietro Tonali; Daniela Trevisan; Michele Zarrelli

doi:10.1016/0022-510X(91)90260-E

Prognosis of myasthenia gravis: A multicenter follow-up study of 844 patients

Ettore Beghi, Carlo Antozzi, Anna P. Batocchi, Ferdinando Cornelio, Vittore Cosi, Amelia Evoli, Mariella Lombardi, Renato Mantegazza, M. Luisa Monticelli, Giovanni Piccolo, Pietro Tonali, Daniela Trevisan, Michele Zarrelli

Research output: Contribution to journal › Article

Abstract

The prognosis of myasthenia gravis (MG) was assessed retrospectively using life-table analysis in 844 patients followed up for a mean period of 5 years in 3 major Italian centers. The chance of achieving at least a 1-year remission after treatment withdrawal (complete remission) was assessed as a specific end-point in the whole population and in selected subgroups with reference to the principal prognostic variables. The cumulative probability of complete remission was 1% by 1 year, 8% by 3 years. 13% by 5 years, and 21% by 10 years. The only variables correlated to the chance of complete remission were younger age at onset of MG, lower severity of symptoms at onset and nadir, and shorter disease duration at diagnosis. In addition, thymectomy and early surgery seemed to influence the chance of remission. Other factors (including the presence of thymoma) did not significantly influence the outcome of the disease.

Original language	English
Pages (from-to)	213-220
Number of pages	8
Journal	Journal of the Neurological Sciences
Volume	106
Issue number	2
DOIs	https://doi.org/10.1016/0022-510X(91)90260-E
Publication status	Published - 1991

Keywords

Multicenter follow-up study
Myasthenia gravis
Prognosis
Surgery
Therapy

ASJC Scopus subject areas

Ageing
Clinical Neurology
Surgery
Neuroscience(all)
Developmental Neuroscience
Neurology

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Beghi, E., Antozzi, C., Batocchi, A. P., Cornelio, F., Cosi, V., Evoli, A., Lombardi, M., Mantegazza, R., Monticelli, M. L., Piccolo, G., Tonali, P., Trevisan, D., & Zarrelli, M. (1991). Prognosis of myasthenia gravis: A multicenter follow-up study of 844 patients. Journal of the Neurological Sciences, 106(2), 213-220. https://doi.org/10.1016/0022-510X(91)90260-E

Prognosis of myasthenia gravis : A multicenter follow-up study of 844 patients. / Beghi, Ettore ; Antozzi, Carlo; Batocchi, Anna P.; Cornelio, Ferdinando; Cosi, Vittore; Evoli, Amelia; Lombardi, Mariella; Mantegazza, Renato; Monticelli, M. Luisa; Piccolo, Giovanni; Tonali, Pietro; Trevisan, Daniela; Zarrelli, Michele.

In: Journal of the Neurological Sciences, Vol. 106, No. 2, 1991, p. 213-220.

Research output: Contribution to journal › Article

Beghi, Ettore ; Antozzi, Carlo ; Batocchi, Anna P. ; Cornelio, Ferdinando ; Cosi, Vittore ; Evoli, Amelia ; Lombardi, Mariella ; Mantegazza, Renato ; Monticelli, M. Luisa ; Piccolo, Giovanni ; Tonali, Pietro ; Trevisan, Daniela ; Zarrelli, Michele. / Prognosis of myasthenia gravis : A multicenter follow-up study of 844 patients. In: Journal of the Neurological Sciences. 1991 ; Vol. 106, No. 2. pp. 213-220.

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