Prognosis of myasthenia gravis: A retrospective study of 380 patients

Vittorio Cosi, Alfredo Rumani, Maria Lombardi, Elda Raiola, Roberto Bergamaschi, Giovanni Piccolo, Antonietta Citterio, Carlo Berzuini

Research output: Contribution to journalArticlepeer-review

Abstract

The 9139 follow-up records of 438 myasthenia gravis (MG) patients were reviewed. Excluding those patients who were diagnosed 5 or more years after symptom onset (n = 37) and those who experienced only oculomotor symptoms throughout follow-up (n = 21), there were 380 patients. A survival analysis approach was used to assess the influence of prognostic factors on the following endpoints: (a) stable complete remission. (b) complete remission of at least 6 months and (c) pharmacological remission of at least 6 months. Early diagnosis was associated with a better prognosis with respect to all endpoints. Thymectomy also improved the prognosis but only for those patients without thymoma. Later MG onset was associated with a higher tendency to achieve pharmacological remission.

Original languageEnglish
Pages (from-to)548-555
Number of pages8
JournalJournal of Neurology
Volume244
Issue number9
DOIs
Publication statusPublished - 1997

Keywords

  • Myasthenia gravis
  • Prognosis
  • Retrospective study

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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