Prognosi dell'epilessia frontale notturna (EFN)

Studio di follow-up a lungo termine

Translated title of the contribution: Prognosis of nocturnal frontal lobe epilepsy (NFLE): A long-term follow-up study

L. Licchetta, L. Di Vito, F. Bisulli, S. Musho Ilbeh, I. Naldi, F. Pittau, F. Provini, L. Vignatelli, J. E. Fares, P. Montagna, P. Tinuper

Research output: Contribution to journalArticle

Abstract

Purpose: This study analyses the clinical and prognostic features of 100 patients (pts) with nocturnal frontal lobe epilepsy (NFLE) after a long follow-up. Methods: We selected 100 pts with NFLE according to the following criteria: a history of nocturnal seizures with symptoms suggesting frontal lobe involvement, video-polysomnographic recording of at least one major episode (hypermotor or tonic seizures) or two stereotyped paroxysmal arousals, a follow-up period longer than 5 years and last visit within the last 24 months. All pts underwent a full clinical, neuroradiological and neurophysiological examination. On the basis of seizure frequency at the last visit our population was divided into two groups: pts with Negative Evolution (NE- seizure frequency varying from daily to pluriyearly:) and pts with Positive Evolution (PE- seizure-free for at least 1 year or with sporadic seizure: 42%). Results: The final population of 100 pts (62 males, 38 females) had a mean age at onset of epilepsy of 13.3 ± 10.4 yrs; all pts had a long period of follow-up (mean: 12.9 ± 6.9 yrs). Only ten patients had positive neuroimaging findings; our population included two nuclear families. Genetic tests done on 39 pts were negative. Most pts presented hypermotor seizures (64%), 28% presented tonic asymmetric seizures, and 6% presented both; 2% presented paroxysmal arousal only. Among the PE group,38 pts were seizure-free; the mean age at seizure disappearance was 33.6 ± 15.7 yrs. Among NE pts the mean age at onset of epilepsy was slightly lower than in PE pts (PE 16.5 ± 11.1 yrs vs NE 12.1 ± 9.1 yrs; p = 0.049). No significant differences were observed between the two groups in seizure type, personal history of febrile convulsions (FC), family history of FC, family history of epilepsy and parasomnias, status epilepticus, secondary generalization, seizures also in wakefulness or interictal epileptiform abnormalities. Conclusions: These preliminary data show significant differences between NE and PE pts only for earlier age at onset and high sezure frequency at onset in the NE group, that seems to be a negative prognostic factor.

Original languageItalian
Pages (from-to)125-126
Number of pages2
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number138
Publication statusPublished - 2008

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Frontal Lobe Epilepsy
Seizures
Age of Onset
Epilepsy
Febrile Seizures
Arousal
Parasomnias
Population
Video Recording
Status Epilepticus
Wakefulness
Frontal Lobe

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Prognosi dell'epilessia frontale notturna (EFN) : Studio di follow-up a lungo termine. / Licchetta, L.; Di Vito, L.; Bisulli, F.; Musho Ilbeh, S.; Naldi, I.; Pittau, F.; Provini, F.; Vignatelli, L.; Fares, J. E.; Montagna, P.; Tinuper, P.

In: Bollettino - Lega Italiana contro l'Epilessia, No. 138, 2008, p. 125-126.

Research output: Contribution to journalArticle

Licchetta, L, Di Vito, L, Bisulli, F, Musho Ilbeh, S, Naldi, I, Pittau, F, Provini, F, Vignatelli, L, Fares, JE, Montagna, P & Tinuper, P 2008, 'Prognosi dell'epilessia frontale notturna (EFN): Studio di follow-up a lungo termine', Bollettino - Lega Italiana contro l'Epilessia, no. 138, pp. 125-126.
Licchetta, L. ; Di Vito, L. ; Bisulli, F. ; Musho Ilbeh, S. ; Naldi, I. ; Pittau, F. ; Provini, F. ; Vignatelli, L. ; Fares, J. E. ; Montagna, P. ; Tinuper, P. / Prognosi dell'epilessia frontale notturna (EFN) : Studio di follow-up a lungo termine. In: Bollettino - Lega Italiana contro l'Epilessia. 2008 ; No. 138. pp. 125-126.
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abstract = "Purpose: This study analyses the clinical and prognostic features of 100 patients (pts) with nocturnal frontal lobe epilepsy (NFLE) after a long follow-up. Methods: We selected 100 pts with NFLE according to the following criteria: a history of nocturnal seizures with symptoms suggesting frontal lobe involvement, video-polysomnographic recording of at least one major episode (hypermotor or tonic seizures) or two stereotyped paroxysmal arousals, a follow-up period longer than 5 years and last visit within the last 24 months. All pts underwent a full clinical, neuroradiological and neurophysiological examination. On the basis of seizure frequency at the last visit our population was divided into two groups: pts with Negative Evolution (NE- seizure frequency varying from daily to pluriyearly:) and pts with Positive Evolution (PE- seizure-free for at least 1 year or with sporadic seizure: 42{\%}). Results: The final population of 100 pts (62 males, 38 females) had a mean age at onset of epilepsy of 13.3 ± 10.4 yrs; all pts had a long period of follow-up (mean: 12.9 ± 6.9 yrs). Only ten patients had positive neuroimaging findings; our population included two nuclear families. Genetic tests done on 39 pts were negative. Most pts presented hypermotor seizures (64{\%}), 28{\%} presented tonic asymmetric seizures, and 6{\%} presented both; 2{\%} presented paroxysmal arousal only. Among the PE group,38 pts were seizure-free; the mean age at seizure disappearance was 33.6 ± 15.7 yrs. Among NE pts the mean age at onset of epilepsy was slightly lower than in PE pts (PE 16.5 ± 11.1 yrs vs NE 12.1 ± 9.1 yrs; p = 0.049). No significant differences were observed between the two groups in seizure type, personal history of febrile convulsions (FC), family history of FC, family history of epilepsy and parasomnias, status epilepticus, secondary generalization, seizures also in wakefulness or interictal epileptiform abnormalities. Conclusions: These preliminary data show significant differences between NE and PE pts only for earlier age at onset and high sezure frequency at onset in the NE group, that seems to be a negative prognostic factor.",
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AU - Licchetta, L.

AU - Di Vito, L.

AU - Bisulli, F.

AU - Musho Ilbeh, S.

AU - Naldi, I.

AU - Pittau, F.

AU - Provini, F.

AU - Vignatelli, L.

AU - Fares, J. E.

AU - Montagna, P.

AU - Tinuper, P.

PY - 2008

Y1 - 2008

N2 - Purpose: This study analyses the clinical and prognostic features of 100 patients (pts) with nocturnal frontal lobe epilepsy (NFLE) after a long follow-up. Methods: We selected 100 pts with NFLE according to the following criteria: a history of nocturnal seizures with symptoms suggesting frontal lobe involvement, video-polysomnographic recording of at least one major episode (hypermotor or tonic seizures) or two stereotyped paroxysmal arousals, a follow-up period longer than 5 years and last visit within the last 24 months. All pts underwent a full clinical, neuroradiological and neurophysiological examination. On the basis of seizure frequency at the last visit our population was divided into two groups: pts with Negative Evolution (NE- seizure frequency varying from daily to pluriyearly:) and pts with Positive Evolution (PE- seizure-free for at least 1 year or with sporadic seizure: 42%). Results: The final population of 100 pts (62 males, 38 females) had a mean age at onset of epilepsy of 13.3 ± 10.4 yrs; all pts had a long period of follow-up (mean: 12.9 ± 6.9 yrs). Only ten patients had positive neuroimaging findings; our population included two nuclear families. Genetic tests done on 39 pts were negative. Most pts presented hypermotor seizures (64%), 28% presented tonic asymmetric seizures, and 6% presented both; 2% presented paroxysmal arousal only. Among the PE group,38 pts were seizure-free; the mean age at seizure disappearance was 33.6 ± 15.7 yrs. Among NE pts the mean age at onset of epilepsy was slightly lower than in PE pts (PE 16.5 ± 11.1 yrs vs NE 12.1 ± 9.1 yrs; p = 0.049). No significant differences were observed between the two groups in seizure type, personal history of febrile convulsions (FC), family history of FC, family history of epilepsy and parasomnias, status epilepticus, secondary generalization, seizures also in wakefulness or interictal epileptiform abnormalities. Conclusions: These preliminary data show significant differences between NE and PE pts only for earlier age at onset and high sezure frequency at onset in the NE group, that seems to be a negative prognostic factor.

AB - Purpose: This study analyses the clinical and prognostic features of 100 patients (pts) with nocturnal frontal lobe epilepsy (NFLE) after a long follow-up. Methods: We selected 100 pts with NFLE according to the following criteria: a history of nocturnal seizures with symptoms suggesting frontal lobe involvement, video-polysomnographic recording of at least one major episode (hypermotor or tonic seizures) or two stereotyped paroxysmal arousals, a follow-up period longer than 5 years and last visit within the last 24 months. All pts underwent a full clinical, neuroradiological and neurophysiological examination. On the basis of seizure frequency at the last visit our population was divided into two groups: pts with Negative Evolution (NE- seizure frequency varying from daily to pluriyearly:) and pts with Positive Evolution (PE- seizure-free for at least 1 year or with sporadic seizure: 42%). Results: The final population of 100 pts (62 males, 38 females) had a mean age at onset of epilepsy of 13.3 ± 10.4 yrs; all pts had a long period of follow-up (mean: 12.9 ± 6.9 yrs). Only ten patients had positive neuroimaging findings; our population included two nuclear families. Genetic tests done on 39 pts were negative. Most pts presented hypermotor seizures (64%), 28% presented tonic asymmetric seizures, and 6% presented both; 2% presented paroxysmal arousal only. Among the PE group,38 pts were seizure-free; the mean age at seizure disappearance was 33.6 ± 15.7 yrs. Among NE pts the mean age at onset of epilepsy was slightly lower than in PE pts (PE 16.5 ± 11.1 yrs vs NE 12.1 ± 9.1 yrs; p = 0.049). No significant differences were observed between the two groups in seizure type, personal history of febrile convulsions (FC), family history of FC, family history of epilepsy and parasomnias, status epilepticus, secondary generalization, seizures also in wakefulness or interictal epileptiform abnormalities. Conclusions: These preliminary data show significant differences between NE and PE pts only for earlier age at onset and high sezure frequency at onset in the NE group, that seems to be a negative prognostic factor.

KW - Follow-up

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KW - Prognostic factors

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