Prognosis of skin melanoma with regional node metastases (Stage II)

N. Cascinelli, M. Vaglini, M. Nava, M. Santinami, R. Marolda, D. Rovini, C. Clemente, R. Bufalino, A. Morabito

Research output: Contribution to journalArticle

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Abstract

566 stage-II melanoma patients treated at the National Cancer Institute of Milan, Italy, were analyzed to evaluate the prognosis. Among the criteria considered, four were significantly associated with survival when considered as single factors: growth pattern, levels of invasion, the number of involved lymph nodes, and the extent of metastatic growth. As regards growth pattern, the observed 5-year survival rates were 41.9% for superficial spreading melanoma and 20.5% for nodular melanoma (P = 10-3). As regards levels, the 5-year survival rates were as follows: level II, 20.9%; level III 33.1%; level IV, 43.2%; level V, 10.2% (P = 1-03). Patients with a partial node metastasis had 64.5% 10-year survival, while those with extension beyond the capsule had 32.6% 10-year survival (P = 10-9). Patients with one metastatic node had 43.4% 10-year survival, and patients with three or more positive nodes had 26.0% 10-year survival (P = 10-9). Multifactorial analysis shows that growth pattern and extent of node metastases significantly affect survival (P = 10-2 and P = 10-4, respectively) while the number of involved nodes turns to borderline P-value (0.051) and the levels are no longer significant (P = 0.4).

Original languageEnglish
Pages (from-to)240-247
Number of pages8
JournalJournal of Surgical Oncology
Volume25
Issue number4
Publication statusPublished - 1984

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Melanoma
Neoplasm Metastasis
Skin
Survival
Survival Rate
Growth
National Cancer Institute (U.S.)
Italy
Capsules
Intercellular Signaling Peptides and Proteins
Lymph Nodes

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Cascinelli, N., Vaglini, M., Nava, M., Santinami, M., Marolda, R., Rovini, D., ... Morabito, A. (1984). Prognosis of skin melanoma with regional node metastases (Stage II). Journal of Surgical Oncology, 25(4), 240-247.

Prognosis of skin melanoma with regional node metastases (Stage II). / Cascinelli, N.; Vaglini, M.; Nava, M.; Santinami, M.; Marolda, R.; Rovini, D.; Clemente, C.; Bufalino, R.; Morabito, A.

In: Journal of Surgical Oncology, Vol. 25, No. 4, 1984, p. 240-247.

Research output: Contribution to journalArticle

Cascinelli, N, Vaglini, M, Nava, M, Santinami, M, Marolda, R, Rovini, D, Clemente, C, Bufalino, R & Morabito, A 1984, 'Prognosis of skin melanoma with regional node metastases (Stage II)', Journal of Surgical Oncology, vol. 25, no. 4, pp. 240-247.
Cascinelli N, Vaglini M, Nava M, Santinami M, Marolda R, Rovini D et al. Prognosis of skin melanoma with regional node metastases (Stage II). Journal of Surgical Oncology. 1984;25(4):240-247.
Cascinelli, N. ; Vaglini, M. ; Nava, M. ; Santinami, M. ; Marolda, R. ; Rovini, D. ; Clemente, C. ; Bufalino, R. ; Morabito, A. / Prognosis of skin melanoma with regional node metastases (Stage II). In: Journal of Surgical Oncology. 1984 ; Vol. 25, No. 4. pp. 240-247.
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AU - Cascinelli, N.

AU - Vaglini, M.

AU - Nava, M.

AU - Santinami, M.

AU - Marolda, R.

AU - Rovini, D.

AU - Clemente, C.

AU - Bufalino, R.

AU - Morabito, A.

PY - 1984

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N2 - 566 stage-II melanoma patients treated at the National Cancer Institute of Milan, Italy, were analyzed to evaluate the prognosis. Among the criteria considered, four were significantly associated with survival when considered as single factors: growth pattern, levels of invasion, the number of involved lymph nodes, and the extent of metastatic growth. As regards growth pattern, the observed 5-year survival rates were 41.9% for superficial spreading melanoma and 20.5% for nodular melanoma (P = 10-3). As regards levels, the 5-year survival rates were as follows: level II, 20.9%; level III 33.1%; level IV, 43.2%; level V, 10.2% (P = 1-03). Patients with a partial node metastasis had 64.5% 10-year survival, while those with extension beyond the capsule had 32.6% 10-year survival (P = 10-9). Patients with one metastatic node had 43.4% 10-year survival, and patients with three or more positive nodes had 26.0% 10-year survival (P = 10-9). Multifactorial analysis shows that growth pattern and extent of node metastases significantly affect survival (P = 10-2 and P = 10-4, respectively) while the number of involved nodes turns to borderline P-value (0.051) and the levels are no longer significant (P = 0.4).

AB - 566 stage-II melanoma patients treated at the National Cancer Institute of Milan, Italy, were analyzed to evaluate the prognosis. Among the criteria considered, four were significantly associated with survival when considered as single factors: growth pattern, levels of invasion, the number of involved lymph nodes, and the extent of metastatic growth. As regards growth pattern, the observed 5-year survival rates were 41.9% for superficial spreading melanoma and 20.5% for nodular melanoma (P = 10-3). As regards levels, the 5-year survival rates were as follows: level II, 20.9%; level III 33.1%; level IV, 43.2%; level V, 10.2% (P = 1-03). Patients with a partial node metastasis had 64.5% 10-year survival, while those with extension beyond the capsule had 32.6% 10-year survival (P = 10-9). Patients with one metastatic node had 43.4% 10-year survival, and patients with three or more positive nodes had 26.0% 10-year survival (P = 10-9). Multifactorial analysis shows that growth pattern and extent of node metastases significantly affect survival (P = 10-2 and P = 10-4, respectively) while the number of involved nodes turns to borderline P-value (0.051) and the levels are no longer significant (P = 0.4).

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