Abstract
566 stage-II melanoma patients treated at the National Cancer Institute of Milan, Italy, were analyzed to evaluate the prognosis. Among the criteria considered, four were significantly associated with survival when considered as single factors: growth pattern, levels of invasion, the number of involved lymph nodes, and the extent of metastatic growth. As regards growth pattern, the observed 5-year survival rates were 41.9% for superficial spreading melanoma and 20.5% for nodular melanoma (P = 10-3). As regards levels, the 5-year survival rates were as follows: level II, 20.9%; level III 33.1%; level IV, 43.2%; level V, 10.2% (P = 1-03). Patients with a partial node metastasis had 64.5% 10-year survival, while those with extension beyond the capsule had 32.6% 10-year survival (P = 10-9). Patients with one metastatic node had 43.4% 10-year survival, and patients with three or more positive nodes had 26.0% 10-year survival (P = 10-9). Multifactorial analysis shows that growth pattern and extent of node metastases significantly affect survival (P = 10-2 and P = 10-4, respectively) while the number of involved nodes turns to borderline P-value (0.051) and the levels are no longer significant (P = 0.4).
| Original language | English |
|---|---|
| Pages (from-to) | 240-247 |
| Number of pages | 8 |
| Journal | Journal of Surgical Oncology |
| Volume | 25 |
| Issue number | 4 |
| Publication status | Published - 1984 |
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ASJC Scopus subject areas
- Surgery
- Oncology
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Prognosis of skin melanoma with regional node metastases (Stage II). / Cascinelli, N.; Vaglini, M.; Nava, M.; Santinami, M.; Marolda, R.; Rovini, D.; Clemente, C.; Bufalino, R.; Morabito, A.
In: Journal of Surgical Oncology, Vol. 25, No. 4, 1984, p. 240-247.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prognosis of skin melanoma with regional node metastases (Stage II)
AU - Cascinelli, N.
AU - Vaglini, M.
AU - Nava, M.
AU - Santinami, M.
AU - Marolda, R.
AU - Rovini, D.
AU - Clemente, C.
AU - Bufalino, R.
AU - Morabito, A.
PY - 1984
Y1 - 1984
N2 - 566 stage-II melanoma patients treated at the National Cancer Institute of Milan, Italy, were analyzed to evaluate the prognosis. Among the criteria considered, four were significantly associated with survival when considered as single factors: growth pattern, levels of invasion, the number of involved lymph nodes, and the extent of metastatic growth. As regards growth pattern, the observed 5-year survival rates were 41.9% for superficial spreading melanoma and 20.5% for nodular melanoma (P = 10-3). As regards levels, the 5-year survival rates were as follows: level II, 20.9%; level III 33.1%; level IV, 43.2%; level V, 10.2% (P = 1-03). Patients with a partial node metastasis had 64.5% 10-year survival, while those with extension beyond the capsule had 32.6% 10-year survival (P = 10-9). Patients with one metastatic node had 43.4% 10-year survival, and patients with three or more positive nodes had 26.0% 10-year survival (P = 10-9). Multifactorial analysis shows that growth pattern and extent of node metastases significantly affect survival (P = 10-2 and P = 10-4, respectively) while the number of involved nodes turns to borderline P-value (0.051) and the levels are no longer significant (P = 0.4).
AB - 566 stage-II melanoma patients treated at the National Cancer Institute of Milan, Italy, were analyzed to evaluate the prognosis. Among the criteria considered, four were significantly associated with survival when considered as single factors: growth pattern, levels of invasion, the number of involved lymph nodes, and the extent of metastatic growth. As regards growth pattern, the observed 5-year survival rates were 41.9% for superficial spreading melanoma and 20.5% for nodular melanoma (P = 10-3). As regards levels, the 5-year survival rates were as follows: level II, 20.9%; level III 33.1%; level IV, 43.2%; level V, 10.2% (P = 1-03). Patients with a partial node metastasis had 64.5% 10-year survival, while those with extension beyond the capsule had 32.6% 10-year survival (P = 10-9). Patients with one metastatic node had 43.4% 10-year survival, and patients with three or more positive nodes had 26.0% 10-year survival (P = 10-9). Multifactorial analysis shows that growth pattern and extent of node metastases significantly affect survival (P = 10-2 and P = 10-4, respectively) while the number of involved nodes turns to borderline P-value (0.051) and the levels are no longer significant (P = 0.4).
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M3 - Article
VL - 25
SP - 240
EP - 247
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
SN - 0022-4790
IS - 4
ER -