Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 251-259 |
| Number of pages | 9 |
| Journal | HPB |
| Volume | 20 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2018 |
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Prognosis of sporadic resected small (≤2 cm) nonfunctional pancreatic neuroendocrine tumors - a multi-institutional study. / Sallinen, VJ; Le Large, TTY; Tieftrunk, E; Galeev, S; Kovalenko, Z; Haugvik, SP; Antila, A; Franklin, O; Martinez-Moneo, E; Robinson, SM; Panzuto, F; Regenet, N; Muffatti, F; Partelli, S; Wiese, D; Ruszniewski, P; Dousset, B; Edwin, B; Bartsch, DK; Sauvanet, A; Falconi, M; Ceyhan, GO; Gaujoux, S; group, on the behalf of the Pancreas 2000 research.
In: HPB, Vol. 20, No. 3, 2018, p. 251-259.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Prognosis of sporadic resected small (≤2 cm) nonfunctional pancreatic neuroendocrine tumors - a multi-institutional study
AU - Sallinen, VJ
AU - Le Large, TTY
AU - Tieftrunk, E
AU - Galeev, S
AU - Kovalenko, Z
AU - Haugvik, SP
AU - Antila, A
AU - Franklin, O
AU - Martinez-Moneo, E
AU - Robinson, SM
AU - Panzuto, F
AU - Regenet, N
AU - Muffatti, F
AU - Partelli, S
AU - Wiese, D
AU - Ruszniewski, P
AU - Dousset, B
AU - Edwin, B
AU - Bartsch, DK
AU - Sauvanet, A
AU - Falconi, M
AU - Ceyhan, GO
AU - Gaujoux, S
AU - group, on the behalf of the Pancreas 2000 research
PY - 2018
Y1 - 2018
N2 - Background: Malignant potential of small (≤20 mm) nonfunctional pancreatic neuroendocrine tumors (sNF-PNET) is difficult to predict and management remain controversial. The aim of this study was to assess the prognosis of sporadic nonmetastatic sNF-PNETs. Methods: Patients were identified from databases of 16 centers. Outcomes and risk factors for recurrence were identified by uni- and multivariate analyses. Results: sNF-PNET was resected in 210 patients, and 66% (n = 138) were asymptomatic. Median age was 60 years, median tumor size was 15 mm, parenchyma-sparing surgery was performed in 42%. Postoperative mortality was 0.5% (n = 1), severe morbidity rate was 14.3% (n = 30), and 14 of 132 patients (10.6%) with harvested lymph nodes had metastatic lymph nodes. Tumor size, presence of biliary or pancreatic duct dilatation, and WHO grade 2-3 were independently associated with recurrence. Patients with tumors sized ≤10 mm were disease free at last follow-up. The 1-, 3- and 5-year disease-free survival rates for patients with tumors sized 11-20 mm on preoperative imaging were 95.1%, 91.0%, and 87.3%, respectively. Conclusions: In sNF-PNETs, the presence of biliary or pancreatic duct dilatation or WHO grade 2-3 advocate for surgical treatment. In the remaining patients, a wait-and-see policy might be considered. © 2017 The Author(s).
AB - Background: Malignant potential of small (≤20 mm) nonfunctional pancreatic neuroendocrine tumors (sNF-PNET) is difficult to predict and management remain controversial. The aim of this study was to assess the prognosis of sporadic nonmetastatic sNF-PNETs. Methods: Patients were identified from databases of 16 centers. Outcomes and risk factors for recurrence were identified by uni- and multivariate analyses. Results: sNF-PNET was resected in 210 patients, and 66% (n = 138) were asymptomatic. Median age was 60 years, median tumor size was 15 mm, parenchyma-sparing surgery was performed in 42%. Postoperative mortality was 0.5% (n = 1), severe morbidity rate was 14.3% (n = 30), and 14 of 132 patients (10.6%) with harvested lymph nodes had metastatic lymph nodes. Tumor size, presence of biliary or pancreatic duct dilatation, and WHO grade 2-3 were independently associated with recurrence. Patients with tumors sized ≤10 mm were disease free at last follow-up. The 1-, 3- and 5-year disease-free survival rates for patients with tumors sized 11-20 mm on preoperative imaging were 95.1%, 91.0%, and 87.3%, respectively. Conclusions: In sNF-PNETs, the presence of biliary or pancreatic duct dilatation or WHO grade 2-3 advocate for surgical treatment. In the remaining patients, a wait-and-see policy might be considered. © 2017 The Author(s).
U2 - 10.1016/j.hpb.2017.08.034
DO - 10.1016/j.hpb.2017.08.034
M3 - Article
VL - 20
SP - 251
EP - 259
JO - HPB
JF - HPB
SN - 1365-182X
IS - 3
ER -