Prognositic value of proton MR spectroscopy of cerebral hemisphere tumors in children

N. Girard, Z. J. Wang, A. Erbetta, L. N. Sutton, P. C. Phillips, L. B. Rorke, R. A. Zimmerman

Research output: Contribution to journalArticlepeer-review


We studied 14 young people with newly diagnosed hemisphere tumors, aged from 3 to 20 years (average 10 years). All underwent surgery following MR imaging (MRI) and spectroscopy (MRS). The tumors studied were three glioblastomas, one each of ganglio-glioblastoma, primitive neuroectodermal tumor (PNET), rhabdoid teratoid tumor, pilocytic astrocytoma, ependymoma, anaplastic ependymoma, and gliomatosis cerebri, and four gangliogliomas. Four patients died; ten patients are alive (five with stable residual tumor, five with no evident tumor). Images and spectra were acquired on a 1.5-T imager. Proton MRS was performed before gadolinium injection in all but one case. Single-voxel techniques were utilized in all cases, using a spin-echo or STEAM sequence with a long echo time (135 or 270 ms). Peak areas of N-acetyl aspartate (NAA), choline (Cho), and creatine and phosphocreatine (Cr) were assessed. The NAA/Cho peak-area ratio was very low in the patients who died (mean ± s.d. 0.20 ± 0.14), and higher in the patients who are alive (0.74 ± 0.47; P = 0.007 two-tailed t-test). The Cr/Cho peak-area ratio also followed a similar trend for the two groups (mean ± s.d. 0.17 ± 0.07 and 0.49 ± 0.30, respectively; P = 0.01 by two-tailed t-test).

Original languageEnglish
Pages (from-to)121-125
Number of pages5
Issue number2
Publication statusPublished - Feb 1998


  • Brain tumor, pediatric
  • Brain tumors, prognosis
  • Neuro-oncology
  • Proton magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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