TY - JOUR
T1 - Prognostic and predictive biomarkers in resected colon cancer
T2 - Current status and future perspectives for integrating genomics into biomarker discovery
AU - Tejpar, Sabine
AU - Bertagnolli, Monica
AU - Bosman, Fred
AU - Lenz, Heinz Joseph
AU - Garraway, Levi
AU - Waldman, Frederic
AU - Warren, Robert
AU - Bild, Andrea
AU - Collins-Brennan, Denise
AU - Hahn, Hejin
AU - Harkin, D. Paul
AU - Kennedy, Richard
AU - Ilyas, Mohammad
AU - Morreau, Hans
AU - Proutski, Vitali
AU - Swanton, Charles
AU - Tomlinson, Ian
AU - Delorenzi, Mauro
AU - Fiocca, Roberto
AU - van Cutsem, Eric
AU - Roth, Arnaud
PY - 2010/4
Y1 - 2010/4
N2 - The number of agents that are potentially effective in the adjuvant treatment of locally advanced resectable colon cancer is increasing. Consequently, it is important to ascertain which subgroups of patients will benefit from a specific treatment. Despite more than two decades of research into the molecular genetics of colon cancer, there is a lack of prognostic and predictive molecular biomarkers with proven utility in this setting. A secondary objective of the Pan European Trials in Adjuvant Colon Cancer-3 trial, which compared irinotecan in combination with 5-fluorouracil and leucovorin in the postoperative treatment of stage III and stage II colon cancer patients, was to undertake a translational research study to assess a panel of putative prognostic and predictive markers in a large colon cancer patient cohort. The Cancer and Leukemia Group B 89803 trial, in a similar design, also investigated the use of prognostic and predictive biomarkers in this setting. In this article, the authors, who are coinvestigators from these trials and performed similar investigations of biomarker discovery in the adjuvant treatment of colon cancer, review the current status of biomarker research in this field, drawing on their experiences and considering future strategies for biomarker discovery in the postgenomic era.
AB - The number of agents that are potentially effective in the adjuvant treatment of locally advanced resectable colon cancer is increasing. Consequently, it is important to ascertain which subgroups of patients will benefit from a specific treatment. Despite more than two decades of research into the molecular genetics of colon cancer, there is a lack of prognostic and predictive molecular biomarkers with proven utility in this setting. A secondary objective of the Pan European Trials in Adjuvant Colon Cancer-3 trial, which compared irinotecan in combination with 5-fluorouracil and leucovorin in the postoperative treatment of stage III and stage II colon cancer patients, was to undertake a translational research study to assess a panel of putative prognostic and predictive markers in a large colon cancer patient cohort. The Cancer and Leukemia Group B 89803 trial, in a similar design, also investigated the use of prognostic and predictive biomarkers in this setting. In this article, the authors, who are coinvestigators from these trials and performed similar investigations of biomarker discovery in the adjuvant treatment of colon cancer, review the current status of biomarker research in this field, drawing on their experiences and considering future strategies for biomarker discovery in the postgenomic era.
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U2 - 10.1634/theoncologist.2009-0233
DO - 10.1634/theoncologist.2009-0233
M3 - Article
C2 - 20350999
AN - SCOPUS:77951711694
VL - 15
SP - 390
EP - 404
JO - Oncologist
JF - Oncologist
SN - 1083-7159
IS - 4
ER -