Prognostic and predictive factors in recurrent and/or metastatic head and neck squamous cell carcinoma: A review of the literature

Paolo Bossi, Salvatore Alfieri, Primoz Strojan, Robert P. Takes, Fernando López, Antti Mäkitie, Nabil F. Saba, Juan Pablo Rodrigo, Carol Bradford, Carlos Suarez, Mark Zafereo, Arlene A. Forastiere, Jan B. Vermorken, Miquel Quer, Alvaro Sanabria, Ricard Simo, Remco de Bree, Alessandra Rinaldo, Alfio Ferlito

Research output: Contribution to journalReview article

Abstract

The pattern of clinical behaviour and response to treatment of recurrent and/or metastatic head and neck squamous cell carcinoma is heterogeneous. Treatment strategies that can be employed vary from potentially curative salvage surgery and re-irradiation to palliative systemic therapies and best supportive care. The advent of new therapeutic options, in terms of more sophisticated surgical approaches and techniques, highly conformal and precise radiation techniques and immunotherapy may offer improved control of disease and longer survival. Moreover, the epidemiological changes during the last decades, including the increase of human papilloma virus-related oropharyngeal primary tumors, are also reflected in the recurrent and metastatic setting. In this complex context the identification of predictive and prognostic factors is urgently needed to tailor treatment, to increase its efficacy, and to avoid unnecessary toxicities. A better knowledge of prognosis may also help the patients and caregivers in decision making on the optimal choice of care. The purpose of our review is to highlight the current evidence and shortcomings in this field.

Original languageEnglish
Pages (from-to)84-91
Number of pages8
JournalCritical Reviews in Oncology/Hematology
Volume137
DOIs
Publication statusPublished - May 2019

Keywords

  • Head and neck cancer
  • Prognostic and predictive factors
  • Recurrent and/or metastatic disease

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Geriatrics and Gerontology

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    Bossi, P., Alfieri, S., Strojan, P., Takes, R. P., López, F., Mäkitie, A., Saba, N. F., Rodrigo, J. P., Bradford, C., Suarez, C., Zafereo, M., Forastiere, A. A., Vermorken, J. B., Quer, M., Sanabria, A., Simo, R., de Bree, R., Rinaldo, A., & Ferlito, A. (2019). Prognostic and predictive factors in recurrent and/or metastatic head and neck squamous cell carcinoma: A review of the literature. Critical Reviews in Oncology/Hematology, 137, 84-91. https://doi.org/10.1016/j.critrevonc.2019.01.018