Prognostic and predictive role of neutrophil/lymphocytes ratio in metastatic colorectal cancer: a retrospective analysis of the TRIBE study by GONO

E Dell'Aquila, C Cremolini, T Zeppola, S Lonardi, F Bergamo, G Masi, M Stellato, F Marmorino, M Schirripa, F Urbano, M Ronzoni, G Tomasello, A Zaniboni, P Racca, A Buonadonna, G Allegrini, E Fea, S Di Donato, S Chiara, G Tonini & 4 others D Tomcikova, L Boni, A Falcone, D Santini

Research output: Contribution to journalArticle

Abstract

Background: Neutrophil/lymphocyte ratio (NLR), defined as absolute neutrophils count divided by absolute lymphocytes count, has been reported as poor prognostic factor in several neoplastic diseases but only a few data are available about unresectable metastatic colorectal cancer (mCRC) patients (pts). The aim of our study was to evaluate the prognostic and predictive role of NLR in the TRIBE trial.Patients and methods: Pts enrolled in TRIBE trial were included. TRIBE is a multicentre phase III trial randomizing unresectable and previously untreated mCRC pts to receive FOLFOXIRI or FOLFIRI plus bevacizumab. A cut-off value of 3 was adopted to discriminate pts with low (NLR 
Original languageEnglish
Pages (from-to)924-930
Number of pages7
JournalAnnals of Oncology
Volume29
Issue number4
DOIs
Publication statusPublished - Apr 1 2018

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Colorectal Neoplasms
Neutrophils
Lymphocytes
Lymphocyte Count

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Prognostic and predictive role of neutrophil/lymphocytes ratio in metastatic colorectal cancer: a retrospective analysis of the TRIBE study by GONO. / Dell'Aquila, E; Cremolini, C; Zeppola, T; Lonardi, S; Bergamo, F; Masi, G; Stellato, M; Marmorino, F; Schirripa, M; Urbano, F; Ronzoni, M; Tomasello, G; Zaniboni, A; Racca, P; Buonadonna, A; Allegrini, G; Fea, E; Di Donato, S; Chiara, S; Tonini, G; Tomcikova, D; Boni, L; Falcone, A; Santini, D.

In: Annals of Oncology, Vol. 29, No. 4, 01.04.2018, p. 924-930.

Research output: Contribution to journalArticle

Dell'Aquila, E, Cremolini, C, Zeppola, T, Lonardi, S, Bergamo, F, Masi, G, Stellato, M, Marmorino, F, Schirripa, M, Urbano, F, Ronzoni, M, Tomasello, G, Zaniboni, A, Racca, P, Buonadonna, A, Allegrini, G, Fea, E, Di Donato, S, Chiara, S, Tonini, G, Tomcikova, D, Boni, L, Falcone, A & Santini, D 2018, 'Prognostic and predictive role of neutrophil/lymphocytes ratio in metastatic colorectal cancer: a retrospective analysis of the TRIBE study by GONO', Annals of Oncology, vol. 29, no. 4, pp. 924-930. https://doi.org/10.1093/annonc/mdy004
Dell'Aquila, E ; Cremolini, C ; Zeppola, T ; Lonardi, S ; Bergamo, F ; Masi, G ; Stellato, M ; Marmorino, F ; Schirripa, M ; Urbano, F ; Ronzoni, M ; Tomasello, G ; Zaniboni, A ; Racca, P ; Buonadonna, A ; Allegrini, G ; Fea, E ; Di Donato, S ; Chiara, S ; Tonini, G ; Tomcikova, D ; Boni, L ; Falcone, A ; Santini, D. / Prognostic and predictive role of neutrophil/lymphocytes ratio in metastatic colorectal cancer: a retrospective analysis of the TRIBE study by GONO. In: Annals of Oncology. 2018 ; Vol. 29, No. 4. pp. 924-930.
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T1 - Prognostic and predictive role of neutrophil/lymphocytes ratio in metastatic colorectal cancer: a retrospective analysis of the TRIBE study by GONO

AU - Dell'Aquila, E

AU - Cremolini, C

AU - Zeppola, T

AU - Lonardi, S

AU - Bergamo, F

AU - Masi, G

AU - Stellato, M

AU - Marmorino, F

AU - Schirripa, M

AU - Urbano, F

AU - Ronzoni, M

AU - Tomasello, G

AU - Zaniboni, A

AU - Racca, P

AU - Buonadonna, A

AU - Allegrini, G

AU - Fea, E

AU - Di Donato, S

AU - Chiara, S

AU - Tonini, G

AU - Tomcikova, D

AU - Boni, L

AU - Falcone, A

AU - Santini, D

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Background: Neutrophil/lymphocyte ratio (NLR), defined as absolute neutrophils count divided by absolute lymphocytes count, has been reported as poor prognostic factor in several neoplastic diseases but only a few data are available about unresectable metastatic colorectal cancer (mCRC) patients (pts). The aim of our study was to evaluate the prognostic and predictive role of NLR in the TRIBE trial.Patients and methods: Pts enrolled in TRIBE trial were included. TRIBE is a multicentre phase III trial randomizing unresectable and previously untreated mCRC pts to receive FOLFOXIRI or FOLFIRI plus bevacizumab. A cut-off value of 3 was adopted to discriminate pts with low (NLR 

AB - Background: Neutrophil/lymphocyte ratio (NLR), defined as absolute neutrophils count divided by absolute lymphocytes count, has been reported as poor prognostic factor in several neoplastic diseases but only a few data are available about unresectable metastatic colorectal cancer (mCRC) patients (pts). The aim of our study was to evaluate the prognostic and predictive role of NLR in the TRIBE trial.Patients and methods: Pts enrolled in TRIBE trial were included. TRIBE is a multicentre phase III trial randomizing unresectable and previously untreated mCRC pts to receive FOLFOXIRI or FOLFIRI plus bevacizumab. A cut-off value of 3 was adopted to discriminate pts with low (NLR 

U2 - 10.1093/annonc/mdy004

DO - 10.1093/annonc/mdy004

M3 - Article

VL - 29

SP - 924

EP - 930

JO - Annals of Oncology

JF - Annals of Oncology

SN - 0923-7534

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