Prognostic and predictive value of tumour angiogenesis in ovarian carcinomas

Giampietro Gasparini, Emanuela Bonoldi, Giuseppe Viale, Paolo Verderio, Patrizia Boracchi, Gino A. Panizzoni, Umberto Radaelli, Alessandra Di Bacco, Rosa B. Guglielmi, Pierantonio Bevilacqua

Research output: Contribution to journalArticlepeer-review


Experimental studies suggest that angiogenesis plays an important role in the pathogenesis of ascites and progression of ovarian cancer. To evaluate the association of intratumoral microvessel density (IMD) with the conventional clinicopathologic features and to determine the capability of these factors in predicting responsiveness to platinum-based chemotherapy and overall survival (OS) we studied 112 ovarian carcinomas. IMD was determined using the anti-CD31 antibody and immunocytochemistry. In the entire series, we correlated IMD with the other features. In the subgroup of patients with FIGO stage III-IV (60 cases), we correlated the factors studied, determined prior of treatment, with response to therapy and prognosis. The median IMD value, in the 'hot spot', in the entire series was of 48 microvessels/field. IMD values were significantly higher in mucinous carcinomas than in the other histologic types. In FIGO stage III-IV patients IMD, age and performance status (PS) were significantly associated with the probability of pathologic response to chemotherapy in univariate analysis. However, only IMD and PS retained significance in multivariate analysis. The overall capability of the 2 variables to predict response was high. In FIGO stage III-IV patients IMD, age, PS, the amount of post-operative residual disease (FORD), histologic type and response to chemotherapy were significant prognostic indicators of OS in univariate analysis. In multivariate analysis only histologic type, FORD and PS retained significance. The overall capability of these 3 variables to predict OS was satisfactory.

Original languageEnglish
Pages (from-to)205-211
Number of pages7
JournalInternational Journal of Cancer
Issue number3
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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