Abstract
Malignant Pleural Mesothelioma (MPM) is an aggressive disease characterized by a dismal prognosis, mainly due to late diagnosis. To date, there are very few treatment options available and the refractoriness to the majority of therapeutic strategies, leading to consider MPM a relevant problem in public health. Therefore, the identification of novel prognostic markers and alternative therapeutic strategies remain a top priority. Several efforts have been made in this direction and to date a number of studies have investigated the role of microRNA as biomarkers in MPM, identifying the potential prognostic role of miR-29c* and miR-31. Very recently, the first microRNA signature able to discriminate poor or and good prognosis of MPM patients underwent surgery has been published. Very interestingly, several microRNA such as miR-1, miR-16, and miR-34b/c have been identified as potential therapeutic agents. Indeed, the forced expression of these microRNA resulted in anti-tumor effects both in vitro and in vivo. Besides, the introduction of microRNA mimic, some agents such as EphrinA1 and Onconase, seemed to exert anti-tumor effects through specific microRNA. Moreover, microRNA have also been reported to play a role in chemoresistance enhancing the sensitivity to specific drug such as pemetrexed. In this review the most relevant and updated data about the role of microRNA as prognostic markers and therapeutic agents in MPM will be presented, opening new avenues towards improved management of this aggressive disease.
| Original language | English |
|---|---|
| Pages (from-to) | 12-18 |
| Number of pages | 7 |
| Journal | MicroRNA |
| Volume | 5 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Apr 1 2016 |
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Keywords
- Malignant pleural mesothelioma
- microRNA
- Prognosis
- Prognostic signature
- Therapeutic
- Tumor suppressor microRNA
ASJC Scopus subject areas
- Medicine(all)
Cite this
Prognostic and therapeutic implications of microRNA in malignant pleural mesothelioma. / Truini, Anna; Coco, Simona; Genova, Carlo; Mora, Marco; Dal Bello, Maria G.; Vanni, Irene; Alama, Angela; Rijavec, Erika; Barletta, Giulia; Biello, Federica; Maggioni, Claudia; Grossi, Francesco.
In: MicroRNA, Vol. 5, No. 1, 01.04.2016, p. 12-18.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Prognostic and therapeutic implications of microRNA in malignant pleural mesothelioma
AU - Truini, Anna
AU - Coco, Simona
AU - Genova, Carlo
AU - Mora, Marco
AU - Dal Bello, Maria G.
AU - Vanni, Irene
AU - Alama, Angela
AU - Rijavec, Erika
AU - Barletta, Giulia
AU - Biello, Federica
AU - Maggioni, Claudia
AU - Grossi, Francesco
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Malignant Pleural Mesothelioma (MPM) is an aggressive disease characterized by a dismal prognosis, mainly due to late diagnosis. To date, there are very few treatment options available and the refractoriness to the majority of therapeutic strategies, leading to consider MPM a relevant problem in public health. Therefore, the identification of novel prognostic markers and alternative therapeutic strategies remain a top priority. Several efforts have been made in this direction and to date a number of studies have investigated the role of microRNA as biomarkers in MPM, identifying the potential prognostic role of miR-29c* and miR-31. Very recently, the first microRNA signature able to discriminate poor or and good prognosis of MPM patients underwent surgery has been published. Very interestingly, several microRNA such as miR-1, miR-16, and miR-34b/c have been identified as potential therapeutic agents. Indeed, the forced expression of these microRNA resulted in anti-tumor effects both in vitro and in vivo. Besides, the introduction of microRNA mimic, some agents such as EphrinA1 and Onconase, seemed to exert anti-tumor effects through specific microRNA. Moreover, microRNA have also been reported to play a role in chemoresistance enhancing the sensitivity to specific drug such as pemetrexed. In this review the most relevant and updated data about the role of microRNA as prognostic markers and therapeutic agents in MPM will be presented, opening new avenues towards improved management of this aggressive disease.
AB - Malignant Pleural Mesothelioma (MPM) is an aggressive disease characterized by a dismal prognosis, mainly due to late diagnosis. To date, there are very few treatment options available and the refractoriness to the majority of therapeutic strategies, leading to consider MPM a relevant problem in public health. Therefore, the identification of novel prognostic markers and alternative therapeutic strategies remain a top priority. Several efforts have been made in this direction and to date a number of studies have investigated the role of microRNA as biomarkers in MPM, identifying the potential prognostic role of miR-29c* and miR-31. Very recently, the first microRNA signature able to discriminate poor or and good prognosis of MPM patients underwent surgery has been published. Very interestingly, several microRNA such as miR-1, miR-16, and miR-34b/c have been identified as potential therapeutic agents. Indeed, the forced expression of these microRNA resulted in anti-tumor effects both in vitro and in vivo. Besides, the introduction of microRNA mimic, some agents such as EphrinA1 and Onconase, seemed to exert anti-tumor effects through specific microRNA. Moreover, microRNA have also been reported to play a role in chemoresistance enhancing the sensitivity to specific drug such as pemetrexed. In this review the most relevant and updated data about the role of microRNA as prognostic markers and therapeutic agents in MPM will be presented, opening new avenues towards improved management of this aggressive disease.
KW - Malignant pleural mesothelioma
KW - microRNA
KW - Prognosis
KW - Prognostic signature
KW - Therapeutic
KW - Tumor suppressor microRNA
UR - http://www.scopus.com/inward/record.url?scp=85017492367&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85017492367&partnerID=8YFLogxK
U2 - 10.2174/2211536605666160128151018
DO - 10.2174/2211536605666160128151018
M3 - Review article
C2 - 26817512
AN - SCOPUS:85017492367
VL - 5
SP - 12
EP - 18
JO - MicroRNA (Shariqah, United Arab Emirates)
JF - MicroRNA (Shariqah, United Arab Emirates)
SN - 2211-5366
IS - 1
ER -