Prognostic factors and clinical features in patients with leptominengeal metastases from breast cancer: A single center experience

Background: Meningeal carcinomatosis (MC) is a rare complication in breast cancer (BC) with no efficient modality of treatment yet found; overall survival (OS) generally did not exceed six months. We reviewed the experience of the University of Florence focusing on prognostic factors and MC survival. Patients and methods: We analyzed 33 patients treated for MC from BC between 2002 and 2010. Results: Mean OS from MC diagnosis was 4.9 months. At survival analysis clinical stage emerged as the only statistical significant parameter (P=0.009) among BC diagnosis features. Among MC diagnosis parameters, more than three metastases at diagnosis (P=0.037), multimodality treatment (P=0.014) and poor performance status (P=0.003) reached the statistical significance. At multivariate analysis only performance status at MC diagnosis maintained the statistical significance (P=0.0047; HR: 3.34; CI 95% 1.45-7.73). Conclusions: Our experience confirms that performance status is probably the most important prognostic factor in these patients. Multimodality approach is probably the best option.