TY - JOUR
T1 - Prognostic factors and clinical features in patients with leptominengeal metastases from breast cancer
T2 - A single center experience
AU - Meattini, Icro
AU - Livi, Lorenzo
AU - Saieva, Calogero
AU - Franceschini, Davide
AU - Marrazzo, Livia
AU - Greto, Daniela
AU - Scotti, Vieri
AU - Scoccianti, Silvia
AU - Paiar, Fabiola
AU - Bordi, Lorenzo
AU - Nori, Jacopo
AU - Sanchez, Luis
AU - Orzalesi, Lorenzo
AU - Bianchi, Simonetta
AU - Biti, Giampaolo
PY - 2012/10
Y1 - 2012/10
N2 - Background: Meningeal carcinomatosis (MC) is a rare complication in breast cancer (BC) with no efficient modality of treatment yet found; overall survival (OS) generally did not exceed six months. We reviewed the experience of the University of Florence focusing on prognostic factors and MC survival. Patients and methods: We analyzed 33 patients treated for MC from BC between 2002 and 2010. Results: Mean OS from MC diagnosis was 4.9 months. At survival analysis clinical stage emerged as the only statistical significant parameter (P=0.009) among BC diagnosis features. Among MC diagnosis parameters, more than three metastases at diagnosis (P=0.037), multimodality treatment (P=0.014) and poor performance status (P=0.003) reached the statistical significance. At multivariate analysis only performance status at MC diagnosis maintained the statistical significance (P=0.0047; HR: 3.34; CI 95% 1.45-7.73). Conclusions: Our experience confirms that performance status is probably the most important prognostic factor in these patients. Multimodality approach is probably the best option.
AB - Background: Meningeal carcinomatosis (MC) is a rare complication in breast cancer (BC) with no efficient modality of treatment yet found; overall survival (OS) generally did not exceed six months. We reviewed the experience of the University of Florence focusing on prognostic factors and MC survival. Patients and methods: We analyzed 33 patients treated for MC from BC between 2002 and 2010. Results: Mean OS from MC diagnosis was 4.9 months. At survival analysis clinical stage emerged as the only statistical significant parameter (P=0.009) among BC diagnosis features. Among MC diagnosis parameters, more than three metastases at diagnosis (P=0.037), multimodality treatment (P=0.014) and poor performance status (P=0.003) reached the statistical significance. At multivariate analysis only performance status at MC diagnosis maintained the statistical significance (P=0.0047; HR: 3.34; CI 95% 1.45-7.73). Conclusions: Our experience confirms that performance status is probably the most important prognostic factor in these patients. Multimodality approach is probably the best option.
KW - Breast cancer
KW - Leptomeningeal metastases
KW - Meningeal carcinomatosis
KW - Performance status
KW - Prognostic factors
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U2 - 10.1179/1973947812Y.0000000034
DO - 10.1179/1973947812Y.0000000034
M3 - Article
C2 - 23182047
AN - SCOPUS:84866714550
VL - 24
SP - 279
EP - 284
JO - Journal of Chemotherapy
JF - Journal of Chemotherapy
SN - 1120-009X
IS - 5
ER -