Prognostic factors and outcome of HER2+ breast cancer with CNS metastases

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Aim: Trastuzumab prolongs progression-free and overall survival in HER2+ breast cancer (BC), but these are associated with increased distant recurrences and central nervous system metastases (CNSm). We retrospectively evaluated outcome and prognostic factors in CNSm and non-CNSm patients. Methods: Records of HER2+ BC treated in 2000-2017 were reviewed. Results: 283/1171 (24%) HER2+ BC patients developed metastatic disease. 109/283 patients (39%) have CNSm associated with worse prognosis and increased risk of death (hazard ratio: 4.7; 95% CI: 3.5-6.4). Prognostic factors were: number of CNSm (single vs multiple lesions; 3-year overall survival 39 vs 18%; p = 0.003); brain radiation (30 vs 14%; p < 0.001); new HER2-targeting therapies (30.6 vs 22.5%; p = 0.025). Conclusion: Prognosis of BC patients with CNSm has improved using HER2-targeting therapies but remains poor.

Original languageEnglish
Pages (from-to)269-279
Number of pages11
JournalFuture oncology (London, England)
Issue number7
Publication statusPublished - Mar 2020


  • Adult
  • Aged
  • Aged, 80 and over
  • Breast Neoplasms/metabolism
  • Central Nervous System Neoplasms/diagnosis
  • Combined Modality Therapy
  • Female
  • Humans
  • Middle Aged
  • Neoplasm Metastasis
  • Neoplasm Staging
  • Patient Outcome Assessment
  • Prognosis
  • Receptor, ErbB-2/genetics
  • Treatment Outcome


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